AN IMPROVED PROCEDURE FOR THE PREPARATION OF THE GARNER ALDEHYDE AND ITS USE FOR THE SYNTHESIS OF N-PROTECTED 1-HALO-2-(R)-AMINO-3-BUTENES

A MCKILLOP, R J K TAYLOR, R J WATSON, N LEWIS

Research output: Contribution to journalComment/debatepeer-review

Abstract

An improved procedure for the preparation of 1,1-dimethylethyl 2,2-dimethyl-4-(S)-formyloxazolidine-3-carboxylate (Garner aldehyde) is described which avoids the need for methyl iodide and benzene. Elaboration of this aldehyde into the novel chiral building blocks mentioned in the title is also described.

Original languageEnglish
Pages (from-to)31-33
Number of pages3
JournalSYNTHESIS-STUTTGART
Issue number1
Publication statusPublished - Jan 1994

Keywords

  • ALPHA-AMINO ALDEHYDES

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