By the same authors

From the same journal

An integrated portable system for single chip simultaneous measurement of multiple disease associated metabolites

Research output: Contribution to journalArticlepeer-review

Author(s)

  • Samadhan B. Patil
  • Dharmendra S. Dheeman
  • Mohammed A. Al-Rawhani
  • Srinivas Velugotla
  • Bence Nagy
  • Boon Chong Cheah
  • James P. Grant
  • Claudio Accarino
  • Michael P. Barrett
  • David R.S. Cumming

Department/unit(s)

Publication details

JournalBiosensors and Bioelectronics
DateAccepted/In press - 1 Sep 2018
DateE-pub ahead of print - 5 Sep 2018
DatePublished (current) - 30 Dec 2018
Volume122
Number of pages7
Pages (from-to)88-94
Early online date5/09/18
Original languageEnglish

Abstract

Metabolites, the small molecules that underpin life, can act as indicators of the physiological state of the body when their abundance varies, offering routes to diagnosis of many diseases. The ability to assay for multiple metabolites simultaneously will underpin a new generation of precision diagnostic tools. Here, we report the development of a handheld device based on complementary metal oxide semiconductor (CMOS) technology with multiple isolated micro-well reaction zones and integrated optical sensing allowing simultaneous enzyme-based assays of multiple metabolites (choline, xanthine, sarcosine and cholesterol) associated with multiple diseases. These metabolites were measured in clinically relevant concentration range with minimum concentrations measured: 25 μM for choline, 100 μM for xanthine, 1.25 μM for sarcosine and 50 μM for cholesterol. Linking the device to an Android-based user interface allows for quantification of metabolites in serum and urine within 2 min of applying samples to the device. The quantitative performance of the device was validated by comparison to accredited tests for cholesterol and glucose.

Bibliographical note

© 2018 The Authors.

    Research areas

  • CMOS, Ischaemia, Metabolites, Multiplexed detection, Photodiode, Point-of-care detection

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