An open, comparative, study of the efficacy of 0.5% podophyllotoxin lotion and 25% podophyllotoxin solution in the treatment of condylomata acuminata in males and females

G R Kinghorn, A McMillan, F Mulcahy, S Drake, C Lacey, J S Bingham

Research output: Contribution to journalArticlepeer-review


The efficacy and safety of topical treatment for external condylomata acuminata with either self-applied 0.5% podophyllotoxin (PT) or hospital-applied 25% podophyllin (PODO) solution was compared in 138 males and 67 females in an open multicentre study. After one week of treatment, wart clearance was observed in 53% of males and 37% of females in the PT group as compared with 19% of males and 19% of females in the PODO group (P <0.001 in males; P = 0.13 in females). At 5 weeks after commencing treatment, clearance of warts had been achieved in 86% males and 72% females in the PT group as compared with 78% of males and 62% females in the PODO group (P = 0.08 in males; P = 0.14 in females). Treatment had cleared 81% of 180 treated sites in all PT recipients as compared with 61% of 95 treated sites in all PODO recipients (P <0.001). The increased speed of action of PT was associated with an increased incidence of symptoms and signs of inflammation at treatment sites in both males and females (P <0.001). These were generally mild, did not interfere with continuing treatment, and were more frequent in those patients whose warts were eradicated most rapidly. Home-based treatment with 0.5% podophyllotoxin lotion in appropriately instructed patients of either sex is superior in efficacy to outpatient applied 25% podophyllin and has the potential to reduce the number of hospital attendances required in genital wart eradication.
Original languageEnglish
Pages (from-to)194-9
Number of pages6
JournalInternational journal of STD & AIDS
Issue number4
Publication statusPublished - 1993


  • Administration, Topical
  • Adolescent
  • Adult
  • Condylomata Acuminata
  • Female
  • Humans
  • Male
  • Middle Aged
  • Penile Neoplasms
  • Podophyllotoxin
  • Recurrence
  • Remission Induction
  • Sex Factors
  • Solutions
  • Suspensions
  • Vulvar Neoplasms

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