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Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry

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Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry. / Kirk, J M ; Tarbin, J ; Keely, B J .

In: Rapid Communications in Mass Spectrometry, Vol. 20, No. 8, 2006, p. 1247-1252.

Research output: Contribution to journalArticle

Harvard

Kirk, JM, Tarbin, J & Keely, BJ 2006, 'Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry', Rapid Communications in Mass Spectrometry, vol. 20, no. 8, pp. 1247-1252. https://doi.org/10.1002/rcm.2442

APA

Kirk, J. M., Tarbin, J., & Keely, B. J. (2006). Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 20(8), 1247-1252. https://doi.org/10.1002/rcm.2442

Vancouver

Kirk JM, Tarbin J, Keely BJ. Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 2006;20(8):1247-1252. https://doi.org/10.1002/rcm.2442

Author

Kirk, J M ; Tarbin, J ; Keely, B J . / Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry. In: Rapid Communications in Mass Spectrometry. 2006 ; Vol. 20, No. 8. pp. 1247-1252.

Bibtex - Download

@article{3fedd6c0add447aebd6231eafb6603c5,
title = "Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry",
abstract = "Seven androgenic steroids have been converted into steroid hydrazones using Girard P hydrazine and analysed by electrospray ionisation multistage tandem mass spectrometry. The cationic derivatives 17 alpha-testosteronehydrazone, 17 beta-nortestosterone hydrazone, 17 beta-bolasterone hydrazone, 17 alpha-boldenone hydrazone, 17 beta-fluoxymesterone hydrazone, 17 alpha-trenbolone hydrazone and 4-chloroandrosten-3,17-dione hydrazone show good response in positive ion mode with enhancements for the method of up to 33 times relative to the native species. Detailed characterisation of fragmentation pathways reveals structurally specific ions formed by fragmentation of the hydrazine moiety. Comparison of structural similarities among the androgenic steroids allows recognition of common ions/fragmentation processes as well as analyte-specific transitions. The suitability of the derivatisation approach in the screening of heifer urine for the presence of administered hormones has been demonstrated using partially purified urine spiked with a mixture of androgenic steroids. Copyright (c) 2006 John Wiley & Sons, Ltd.",
keywords = "ELECTROSPRAY, DERIVATIZATION, OXOSTEROIDS",
author = "Kirk, {J M} and J Tarbin and Keely, {B J}",
year = "2006",
doi = "10.1002/rcm.2442",
language = "English",
volume = "20",
pages = "1247--1252",
journal = "Rapid communications in mass spectrometry",
issn = "0951-4198",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Analysis of androgenic steroid Girard P hydrazones using multistage tandem mass spectrometry

AU - Kirk, J M

AU - Tarbin, J

AU - Keely, B J

PY - 2006

Y1 - 2006

N2 - Seven androgenic steroids have been converted into steroid hydrazones using Girard P hydrazine and analysed by electrospray ionisation multistage tandem mass spectrometry. The cationic derivatives 17 alpha-testosteronehydrazone, 17 beta-nortestosterone hydrazone, 17 beta-bolasterone hydrazone, 17 alpha-boldenone hydrazone, 17 beta-fluoxymesterone hydrazone, 17 alpha-trenbolone hydrazone and 4-chloroandrosten-3,17-dione hydrazone show good response in positive ion mode with enhancements for the method of up to 33 times relative to the native species. Detailed characterisation of fragmentation pathways reveals structurally specific ions formed by fragmentation of the hydrazine moiety. Comparison of structural similarities among the androgenic steroids allows recognition of common ions/fragmentation processes as well as analyte-specific transitions. The suitability of the derivatisation approach in the screening of heifer urine for the presence of administered hormones has been demonstrated using partially purified urine spiked with a mixture of androgenic steroids. Copyright (c) 2006 John Wiley & Sons, Ltd.

AB - Seven androgenic steroids have been converted into steroid hydrazones using Girard P hydrazine and analysed by electrospray ionisation multistage tandem mass spectrometry. The cationic derivatives 17 alpha-testosteronehydrazone, 17 beta-nortestosterone hydrazone, 17 beta-bolasterone hydrazone, 17 alpha-boldenone hydrazone, 17 beta-fluoxymesterone hydrazone, 17 alpha-trenbolone hydrazone and 4-chloroandrosten-3,17-dione hydrazone show good response in positive ion mode with enhancements for the method of up to 33 times relative to the native species. Detailed characterisation of fragmentation pathways reveals structurally specific ions formed by fragmentation of the hydrazine moiety. Comparison of structural similarities among the androgenic steroids allows recognition of common ions/fragmentation processes as well as analyte-specific transitions. The suitability of the derivatisation approach in the screening of heifer urine for the presence of administered hormones has been demonstrated using partially purified urine spiked with a mixture of androgenic steroids. Copyright (c) 2006 John Wiley & Sons, Ltd.

KW - ELECTROSPRAY

KW - DERIVATIZATION

KW - OXOSTEROIDS

U2 - 10.1002/rcm.2442

DO - 10.1002/rcm.2442

M3 - Article

VL - 20

SP - 1247

EP - 1252

JO - Rapid communications in mass spectrometry

T2 - Rapid communications in mass spectrometry

JF - Rapid communications in mass spectrometry

SN - 0951-4198

IS - 8

ER -