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From the same journal

Ancient genomics

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Clio Der Sarkissian
  • Morten E. Allentoft
  • María C. Ávila-Arcos
  • Ross Barnett
  • Paula F Campos
  • Enrico Cappellini
  • Luca Ermini
  • Ruth Fernández
  • Rute A R da Fonseca
  • Aurélien Ginolhac
  • Anders J. Hansen
  • Hákon Jónsson
  • Thorfinn Sand Korneliussen
  • Ashot Margaryan
  • Michael D. Martin
  • J. Víctor Moreno-Mayar
  • Maanasa Raghavan
  • Morten Rasmussen
  • Marcela Sandoval Velasco
  • Hannes Schroeder
  • Mikkel Schubert
  • Andaine Seguin-Orlando
  • M. Thomas P. Gilbert
  • Eske Willerslev
  • Ludovic Orlando

Department/unit(s)

Publication details

JournalPhilosophical Transactions Of The Royal Society Of London Series B - Biological Sciences
DatePublished - 19 Jan 2015
Issue number1660
Volume370
Number of pages12
Original languageEnglish

Abstract

The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.

    Research areas

  • Ancient DNA, Genomics, Next generation sequencing

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