Antigen processing and presentation: modelling with Leishmania

P M Kaye; A J Curry; G J Bancroft; T Lang

Antigen processing and presentation: modelling with Leishmania

P M Kaye, A J Curry, G J Bancroft, T Lang

The Hull York Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Most foreign antigens are "processed" by APC into a form in which they can bind MHC molecules and be recognised by the TCR. Functional and immuno-gold labelling studies have been used to determine the putative sites of MHC-Ag interaction following uptake of Leishmania donovani into a phagolysosome. During infection with this parasite in vivo, upregulation of class II occurs. Based on studies using scid mice, NK cells appear to contribute little to this process. During chronic infection, however, APC function is diminished in spite of high class II levels. We propose that a lack of coordinate costimulator expression may lead to subsequent loss of T cell function late in infection, by a mechanism involving the induction of T cell unresponsiveness.

Original language	English
Pages (from-to)	13-9
Number of pages	7
Journal	Behring Institute Mitteilungen
Issue number	88
Publication status	Published - Feb 1991

Keywords

Animals
Antigen-Presenting Cells
Antigens, Protozoan
Humans
Leishmaniasis, Visceral
Macrophages
Major Histocompatibility Complex
Models, Biological

Cite this

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title = "Antigen processing and presentation: modelling with Leishmania",

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year = "1991",

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T2 - modelling with Leishmania

AU - Kaye, P M

AU - Curry, A J

AU - Bancroft, G J

AU - Lang, T

PY - 1991/2

Y1 - 1991/2

N2 - Most foreign antigens are "processed" by APC into a form in which they can bind MHC molecules and be recognised by the TCR. Functional and immuno-gold labelling studies have been used to determine the putative sites of MHC-Ag interaction following uptake of Leishmania donovani into a phagolysosome. During infection with this parasite in vivo, upregulation of class II occurs. Based on studies using scid mice, NK cells appear to contribute little to this process. During chronic infection, however, APC function is diminished in spite of high class II levels. We propose that a lack of coordinate costimulator expression may lead to subsequent loss of T cell function late in infection, by a mechanism involving the induction of T cell unresponsiveness.

AB - Most foreign antigens are "processed" by APC into a form in which they can bind MHC molecules and be recognised by the TCR. Functional and immuno-gold labelling studies have been used to determine the putative sites of MHC-Ag interaction following uptake of Leishmania donovani into a phagolysosome. During infection with this parasite in vivo, upregulation of class II occurs. Based on studies using scid mice, NK cells appear to contribute little to this process. During chronic infection, however, APC function is diminished in spite of high class II levels. We propose that a lack of coordinate costimulator expression may lead to subsequent loss of T cell function late in infection, by a mechanism involving the induction of T cell unresponsiveness.

KW - Animals

KW - Antigen-Presenting Cells

KW - Antigens, Protozoan

KW - Humans

KW - Leishmaniasis, Visceral

KW - Macrophages

KW - Major Histocompatibility Complex

KW - Models, Biological

M3 - Article

C2 - 2049030

SN - 0301-0457

SP - 13

EP - 19

JO - Behring Institute Mitteilungen

JF - Behring Institute Mitteilungen

IS - 88

ER -