Antioxidant-micronutrients and HIV infection

C J Lacey, M E Murphy, M J Sanderson, E F Monteiro, A Vail, C J Schorah

Research output: Contribution to journalArticlepeer-review


We measured plasma levels of all the antioxidant-micronutrients in subjects with HIV infection and controls. Plasma levels of all the carotenoids, including lutein, cryptoxanthin, lycopene, alpha-carotene and beta-carotene as well as vitamins A, C and E and cholesterol were assayed in 35 subjects with HIV infection and 38 controls. We found a significant depletion of all the carotenoids (P <0.001) and vitamin C (P <0.01) and cholesterol (P <0.001) but not vitamins A or E in HIV-infected subjects. Further analysis of the HIV-infected subjects revealed that plasma levels of 4 of the groups of carotenoids and cholesterol were correlated with CD4 count but that beta-carotene and vitamins A, C and E were not. These results are reviewed in the light of the published literature and we conclude that these abnormalities of antioxidant-micronutrients are likely to reflect a metabolic phenomenon associated with HIV infection. However, an additional contribution to these deficiencies from malabsorption later in HIV disease cannot be ruled out.
Original languageEnglish
Pages (from-to)485-9
Number of pages5
JournalInternational journal of STD & AIDS
Issue number7
Publication statusPublished - 1996


  • Adult
  • Antioxidants
  • Female
  • HIV Infections
  • HIV-1
  • Humans
  • Male
  • Micronutrients

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