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Application of resonant cavity perturbation to in-vivo segmental hydration measurement

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Application of resonant cavity perturbation to in-vivo segmental hydration measurement. / Robinson, M. P.; Flintoft, Ian David; Dawson, L.; Clegg, J.; Truscott, J. G.; Zhu, X.

In: Measurement Science and Technology, Vol. 21, No. 1, 015804, 01.2010, p. 1-10.

Research output: Contribution to journalArticle

Harvard

Robinson, MP, Flintoft, ID, Dawson, L, Clegg, J, Truscott, JG & Zhu, X 2010, 'Application of resonant cavity perturbation to in-vivo segmental hydration measurement', Measurement Science and Technology, vol. 21, no. 1, 015804, pp. 1-10. https://doi.org/10.1088/0957-0233/21/1/015804

APA

Robinson, M. P., Flintoft, I. D., Dawson, L., Clegg, J., Truscott, J. G., & Zhu, X. (2010). Application of resonant cavity perturbation to in-vivo segmental hydration measurement. Measurement Science and Technology, 21(1), 1-10. [015804]. https://doi.org/10.1088/0957-0233/21/1/015804

Vancouver

Robinson MP, Flintoft ID, Dawson L, Clegg J, Truscott JG, Zhu X. Application of resonant cavity perturbation to in-vivo segmental hydration measurement. Measurement Science and Technology. 2010 Jan;21(1):1-10. 015804. https://doi.org/10.1088/0957-0233/21/1/015804

Author

Robinson, M. P. ; Flintoft, Ian David ; Dawson, L. ; Clegg, J. ; Truscott, J. G. ; Zhu, X. / Application of resonant cavity perturbation to in-vivo segmental hydration measurement. In: Measurement Science and Technology. 2010 ; Vol. 21, No. 1. pp. 1-10.

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@article{f3e20e65c5704255b01aa42513ccc789,
title = "Application of resonant cavity perturbation to in-vivo segmental hydration measurement",
abstract = "The dielectric properties of biological tissues at radio and microwave frequencies are strongly correlated with tissue water content. Localized, in vivo measurement of permittivity and conductivity should therefore provide useful clinical information in diseases involving abnormal hydration, such as lymphoedema. We have developed an open-geometry sensor for segmental hydration studies based on a flat cavity resonator operating at 300 MHz, and have demonstrated that the changes in its resonant frequency and Q-factor were significantly greater when it was applied to a swollen, oedematous finger, compared to an uninjured finger of similar size. The resonant sensor was calibrated with reference liquids in vials inserted through holes in its cavity plates, and we found that a modified resonant cavity perturbation formula, with coefficients empirically optimized by means of a genetic algorithm, yielded good agreement with literature values of complex permittivity. However, extending the length of the sample containers leads to measurement artefacts owing to antenna currents with associated radiated energy losses. A detailed simulation of the system with a full-wave solver using Method-of-Moments enabled us to estimate the current distribution and energy balance, and thus take steps towards mitigating these effects and enabling the system to make quantitative in vivo measurements of tissue dielectric properties.",
keywords = "dielectric measurement, permittivity, conductivity, resonant cavity, hydration, genetic algorithm, computational electromagnetics, COMPLEX PERMITTIVITY, DIELECTRIC-PROPERTIES, WATER-CONTENT, LYMPHEDEMA, LIQUIDS, TISSUES, VOLUME, SKIN",
author = "Robinson, {M. P.} and Flintoft, {Ian David} and L. Dawson and J. Clegg and Truscott, {J. G.} and X. Zhu",
year = "2010",
month = "1",
doi = "10.1088/0957-0233/21/1/015804",
language = "English",
volume = "21",
pages = "1--10",
journal = "Measurement Science and Technology",
issn = "0957-0233",
publisher = "IOP Publishing Ltd.",
number = "1",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Application of resonant cavity perturbation to in-vivo segmental hydration measurement

AU - Robinson, M. P.

AU - Flintoft, Ian David

AU - Dawson, L.

AU - Clegg, J.

AU - Truscott, J. G.

AU - Zhu, X.

PY - 2010/1

Y1 - 2010/1

N2 - The dielectric properties of biological tissues at radio and microwave frequencies are strongly correlated with tissue water content. Localized, in vivo measurement of permittivity and conductivity should therefore provide useful clinical information in diseases involving abnormal hydration, such as lymphoedema. We have developed an open-geometry sensor for segmental hydration studies based on a flat cavity resonator operating at 300 MHz, and have demonstrated that the changes in its resonant frequency and Q-factor were significantly greater when it was applied to a swollen, oedematous finger, compared to an uninjured finger of similar size. The resonant sensor was calibrated with reference liquids in vials inserted through holes in its cavity plates, and we found that a modified resonant cavity perturbation formula, with coefficients empirically optimized by means of a genetic algorithm, yielded good agreement with literature values of complex permittivity. However, extending the length of the sample containers leads to measurement artefacts owing to antenna currents with associated radiated energy losses. A detailed simulation of the system with a full-wave solver using Method-of-Moments enabled us to estimate the current distribution and energy balance, and thus take steps towards mitigating these effects and enabling the system to make quantitative in vivo measurements of tissue dielectric properties.

AB - The dielectric properties of biological tissues at radio and microwave frequencies are strongly correlated with tissue water content. Localized, in vivo measurement of permittivity and conductivity should therefore provide useful clinical information in diseases involving abnormal hydration, such as lymphoedema. We have developed an open-geometry sensor for segmental hydration studies based on a flat cavity resonator operating at 300 MHz, and have demonstrated that the changes in its resonant frequency and Q-factor were significantly greater when it was applied to a swollen, oedematous finger, compared to an uninjured finger of similar size. The resonant sensor was calibrated with reference liquids in vials inserted through holes in its cavity plates, and we found that a modified resonant cavity perturbation formula, with coefficients empirically optimized by means of a genetic algorithm, yielded good agreement with literature values of complex permittivity. However, extending the length of the sample containers leads to measurement artefacts owing to antenna currents with associated radiated energy losses. A detailed simulation of the system with a full-wave solver using Method-of-Moments enabled us to estimate the current distribution and energy balance, and thus take steps towards mitigating these effects and enabling the system to make quantitative in vivo measurements of tissue dielectric properties.

KW - dielectric measurement

KW - permittivity

KW - conductivity

KW - resonant cavity

KW - hydration

KW - genetic algorithm

KW - computational electromagnetics

KW - COMPLEX PERMITTIVITY

KW - DIELECTRIC-PROPERTIES

KW - WATER-CONTENT

KW - LYMPHEDEMA

KW - LIQUIDS

KW - TISSUES

KW - VOLUME

KW - SKIN

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U2 - 10.1088/0957-0233/21/1/015804

DO - 10.1088/0957-0233/21/1/015804

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VL - 21

SP - 1

EP - 10

JO - Measurement Science and Technology

T2 - Measurement Science and Technology

JF - Measurement Science and Technology

SN - 0957-0233

IS - 1

M1 - 015804

ER -