Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

D Gunnell; S E Oliver; T J Peters; J L Donovan; R Persad; M Maynard; D Gillatt; A Pearce; F C Hamdy; D E Neal; J M P Holly

doi:10.1038/sj.bjc.6600946

Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

D Gunnell, S E Oliver, T J Peters, J L Donovan, R Persad, M Maynard, D Gillatt, A Pearce, F C Hamdy, D E Neal, J M P Holly

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet - cancer associations.

Original language	English
Pages (from-to)	1682-1686
Number of pages	5
Journal	British journal of cancer
Volume	88
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6600946
Publication status	Published - 2 Jun 2003

Keywords

prostate cancer
IGF-I
IGFBP-3
diet
epidemiology
GROWTH-FACTOR-I
BINDING PROTEIN-3
COLORECTAL-CANCER
RISK
LYCOPENE
PROGRESSION
INSULIN-LIKE-GROWTH-FACTOR-1
POPULATION
PRODUCTS
TOMATOES

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10.1038/sj.bjc.6600946

Cite this

Gunnell, D., Oliver, S. E., Peters, T. J., Donovan, J. L., Persad, R., Maynard, M., Gillatt, D., Pearce, A., Hamdy, F. C., Neal, D. E., & Holly, J. M. P. (2003). Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men. British journal of cancer, 88(11), 1682-1686. https://doi.org/10.1038/sj.bjc.6600946

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abstract = "We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet - cancer associations.",

keywords = "prostate cancer, IGF-I, IGFBP-3, diet, epidemiology, GROWTH-FACTOR-I, BINDING PROTEIN-3, COLORECTAL-CANCER, RISK, LYCOPENE, PROGRESSION, INSULIN-LIKE-GROWTH-FACTOR-1, POPULATION, PRODUCTS, TOMATOES",

author = "D Gunnell and Oliver, {S E} and Peters, {T J} and Donovan, {J L} and R Persad and M Maynard and D Gillatt and A Pearce and Hamdy, {F C} and Neal, {D E} and Holly, {J M P}",

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Gunnell, D, Oliver, SE, Peters, TJ, Donovan, JL, Persad, R, Maynard, M, Gillatt, D, Pearce, A, Hamdy, FC, Neal, DE & Holly, JMP 2003, 'Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men', British journal of cancer, vol. 88, no. 11, pp. 1682-1686. https://doi.org/10.1038/sj.bjc.6600946

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T1 - Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

AU - Gunnell, D

AU - Oliver, S E

AU - Peters, T J

AU - Donovan, J L

AU - Persad, R

AU - Maynard, M

AU - Gillatt, D

AU - Pearce, A

AU - Hamdy, F C

AU - Neal, D E

AU - Holly, J M P

PY - 2003/6/2

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N2 - We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet - cancer associations.

AB - We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet - cancer associations.

KW - prostate cancer

KW - IGF-I

KW - IGFBP-3

KW - diet

KW - epidemiology

KW - GROWTH-FACTOR-I

KW - BINDING PROTEIN-3

KW - COLORECTAL-CANCER

KW - RISK

KW - LYCOPENE

KW - PROGRESSION

KW - INSULIN-LIKE-GROWTH-FACTOR-1

KW - POPULATION

KW - PRODUCTS

KW - TOMATOES

U2 - 10.1038/sj.bjc.6600946

DO - 10.1038/sj.bjc.6600946

M3 - Article

VL - 88

SP - 1682

EP - 1686

JO - British journal of cancer

JF - British journal of cancer

SN - 0007-0920

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ER -