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From the same journal

Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • D Gunnell
  • S E Oliver
  • T J Peters
  • J L Donovan
  • R Persad
  • M Maynard
  • D Gillatt
  • A Pearce
  • F C Hamdy
  • D E Neal
  • J M P Holly

Department/unit(s)

Publication details

JournalBritish journal of cancer
DatePublished - 2 Jun 2003
Issue number11
Volume88
Number of pages5
Pages (from-to)1682-1686
Original languageEnglish

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet - cancer associations.

    Research areas

  • prostate cancer, IGF-I, IGFBP-3, diet, epidemiology, GROWTH-FACTOR-I, BINDING PROTEIN-3, COLORECTAL-CANCER, RISK, LYCOPENE, PROGRESSION, INSULIN-LIKE-GROWTH-FACTOR-1, POPULATION, PRODUCTS, TOMATOES

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