Activities per year
Abstract
Biocatalytic imine reduction has been a topic of intense research by the artificial metalloenzyme community in recent years. Artificial constructs, together with natural enzymes, have been engineered to produce chiral amines with high enantioselectivity. This review examines the design of the main classes of artificial imine reductases reported thus far and summarises approaches to enhancing their catalytic performance using complementary methods. Examples of utilising these biocatalysts in vivo or in multi-enzyme cascades have demonstrated the potential that artIREDs can offer, however, at this time their use in biocatalysis remains limited. This review explores the current scope of artIREDs and the strategies used for catalyst improvement, and examines the potential for artIREDs in the future.
Original language | English |
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Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | RSC Chemical Biology |
Early online date | 16 Oct 2020 |
DOIs | |
Publication status | Published - 16 Oct 2020 |
Bibliographical note
© 2020, The Author(s).Activities
- 1 Invited talk
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Exploiting siderophores in the development of antimicrobials and artificial enzymes
Anne-Kathrin Duhme-Klair (Keynote/plenary speaker)
21 May 2021Activity: Talk or presentation › Invited talk
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Redox-reversible artificial metalloenzymes
Duhme-Klair, A., Johnson, S. D. & Wilson, K. S.
27/01/20 → 31/10/23
Project: Research project (funded) › Research
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Siderophores as anchors in artificial metalloenzymes
Duhme-Klair, A. & Wilson, K. S.
31/12/14 → 30/12/17
Project: Research project (funded) › Research