Artificial metalloenzymes: the powerful alliance between protein scaffolds and organometallic catalysts

TY - JOUR

T1 - Artificial metalloenzymes

T2 - the powerful alliance between protein scaffolds and organometallic catalysts

AU - Large, Benjamin

AU - Baranska, Natalia

AU - Booth, Rosalind

AU - Wilson, Keith Sanderson

AU - Duhme-Klair, Anne-Kathrin

N1 - This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - In recent years, substantial advances have been made in the development of artificial metalloenzymes. These hybrid bioinorganic catalysts have seen their selectivity improved through techniques including site-directed and site-saturation mutagenesis and directed evolution. Their scope has been expanded by the introduction of various abiological metal catalysts, the development of new anchoring strategies and new designs to enhance their reusability by conceiving modular and reversible assemblies. This review highlights a selection of the most significant advances made in the last two years and their contribution to the development of a more sustainable chemistry

AB - In recent years, substantial advances have been made in the development of artificial metalloenzymes. These hybrid bioinorganic catalysts have seen their selectivity improved through techniques including site-directed and site-saturation mutagenesis and directed evolution. Their scope has been expanded by the introduction of various abiological metal catalysts, the development of new anchoring strategies and new designs to enhance their reusability by conceiving modular and reversible assemblies. This review highlights a selection of the most significant advances made in the last two years and their contribution to the development of a more sustainable chemistry

U2 - 10.1016/j.cogsc.2020.100420

DO - 10.1016/j.cogsc.2020.100420

M3 - Review article

SN - 2452-2236

VL - 28

JO - Current Opinion in Green and Sustainable Chemistry

JF - Current Opinion in Green and Sustainable Chemistry

M1 - 100420

ER -