Assembling the bacterial segrosome

F  Hayes; D  Barilla

doi:10.1016/j.tibs.2006.03.002

Assembling the bacterial segrosome

F Hayes, D Barilla

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Genome segregation in prokaryotes; is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation.

Original language	English
Pages (from-to)	247-250
Number of pages	4
Journal	Trends in biochemical sciences
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.tibs.2006.03.002
Publication status	Published - May 2006

Keywords

CHROMOSOME SEGREGATION
DNA SEGREGATION
PARTITION COMPLEX
PLASMID
P1
SPECIFICITY
HOMOLOG
MECHANISM
BINDING
MITOSIS

Access to Document

10.1016/j.tibs.2006.03.002

Cite this

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title = "Assembling the bacterial segrosome",

abstract = "Genome segregation in prokaryotes; is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation.",

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KW - CHROMOSOME SEGREGATION

KW - DNA SEGREGATION

KW - PARTITION COMPLEX

KW - PLASMID

KW - P1

KW - SPECIFICITY

KW - HOMOLOG

KW - MECHANISM

KW - BINDING

KW - MITOSIS

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JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

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