Assessment of systematic effects of methodological characteristics on candidate genetic associations

TY - JOUR

T1 - Assessment of systematic effects of methodological characteristics on candidate genetic associations

AU - Aljasir, Badr

AU - Ioannidis, John P A

AU - Yurkiewich, Alex

AU - Moher, David

AU - Higgins, Julian P T

AU - Arora, Paul

AU - Little, Julian

PY - 2013

Y1 - 2013

N2 - Candidate genetic association studies have been found to have a low replication rate in the past. Here, we aimed to assess whether aspects of reported methodological characteristics in genetic association studies may be related to the magnitude of effects observed. An observational, literature-based investigation of 511 case-control studies of genetic association studies indexed in 2007, was undertaken. Meta-regression analyses were used to assess the relationship between 23 reported methodological characteristics and the magnitude of genetic associations. The 511 studies had been conducted in 52 countries and were published in 220 journals (median impact factor 5.1). The multivariate meta-regression model of methodological characteristics plus disease category accounted for 17.2 % of the between-study variance in the magnitude of the reported genetic associations. Our findings are consistent with the view that better conducted and better reported genetic association research may lead to less inflated results.

AB - Candidate genetic association studies have been found to have a low replication rate in the past. Here, we aimed to assess whether aspects of reported methodological characteristics in genetic association studies may be related to the magnitude of effects observed. An observational, literature-based investigation of 511 case-control studies of genetic association studies indexed in 2007, was undertaken. Meta-regression analyses were used to assess the relationship between 23 reported methodological characteristics and the magnitude of genetic associations. The 511 studies had been conducted in 52 countries and were published in 220 journals (median impact factor 5.1). The multivariate meta-regression model of methodological characteristics plus disease category accounted for 17.2 % of the between-study variance in the magnitude of the reported genetic associations. Our findings are consistent with the view that better conducted and better reported genetic association research may lead to less inflated results.

UR - http://www.scopus.com/inward/record.url?scp=84867656043&partnerID=8YFLogxK

U2 - 10.1007/s00439-012-1237-4

DO - 10.1007/s00439-012-1237-4

M3 - Article

C2 - 23095857

SN - 0340-6717

VL - 132

SP - 167

EP - 178

JO - Human Genetics

JF - Human Genetics

IS - 2

ER -