Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci

Sophia S Wang; Claire M Vajdic; Martha S Linet; Susan L Slager; Jenna Voutsinas; Alexandra Nieters; Silvia de Sanjose; Wendy Cozen; Graciela S Alarcón; Otoniel Martinez-Maza; Elizabeth E Brown; Paige M Bracci; Tracy Lightfoot; Jennifer Turner; Henrik Hjalgrim; John J Spinelli; Tongzhang Zheng; Lindsay M Morton; Brenda M Birmann; Christopher R Flowers; Ora Paltiel; Nikolaus Becker; Elizabeth A Holly; Eleanor Kane; Dennis Weisenburger; Marc Maynadie; Pierluigi Cocco; Lenka Foretova; Anthony Staines; Scott Davis; Richard Severson; James R Cerhan; Elizabeth C Breen; Qing Lan; Angela Brooks-Wilson; Anneclaire J De Roos; Martyn T Smith; Eve Roman; Paolo Boffetta; Anne Kricker; Yawei Zhang; Christine Skibola; Stephen J Chanock; Nathaniel Rothman; Yolanda Benavente; Patricia Hartge; Karin E Smedby

doi:10.1093/aje/kwu290

Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci

Sophia S Wang, Claire M Vajdic, Martha S Linet, Susan L Slager, Jenna Voutsinas, Alexandra Nieters, Silvia de Sanjose, Wendy Cozen, Graciela S Alarcón, Otoniel Martinez-Maza, Elizabeth E Brown, Paige M Bracci, Tracy Lightfoot, Jennifer Turner, Henrik Hjalgrim, John J Spinelli, Tongzhang Zheng, Lindsay M Morton, Brenda M Birmann, Christopher R FlowersOra Paltiel, Nikolaus Becker, Elizabeth A Holly, Eleanor Kane, Dennis Weisenburger, Marc Maynadie, Pierluigi Cocco, Lenka Foretova, Anthony Staines, Scott Davis, Richard Severson, James R Cerhan, Elizabeth C Breen, Qing Lan, Angela Brooks-Wilson, Anneclaire J De Roos, Martyn T Smith, Eve Roman, Paolo Boffetta, Anne Kricker, Yawei Zhang, Christine Skibola, Stephen J Chanock, Nathaniel Rothman, Yolanda Benavente, Patricia Hartge, Karin E Smedby

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

Original language	English
Journal	American Journal of Epidemiology
Volume	181
Issue number	6
Early online date	23 Feb 2015
DOIs	https://doi.org/10.1093/aje/kwu290
Publication status	Published - Mar 2015

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Wang, S. S., Vajdic, C. M., Linet, M. S., Slager, S. L., Voutsinas, J., Nieters, A., de Sanjose, S., Cozen, W., Alarcón, G. S., Martinez-Maza, O., Brown, E. E., Bracci, P. M., Lightfoot, T., Turner, J., Hjalgrim, H., Spinelli, J. J., Zheng, T., Morton, L. M., Birmann, B. M., ... Smedby, K. E. (2015). Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci. American Journal of Epidemiology, 181(6). https://doi.org/10.1093/aje/kwu290

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title = "Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci",

abstract = "Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).",

author = "Wang, {Sophia S} and Vajdic, {Claire M} and Linet, {Martha S} and Slager, {Susan L} and Jenna Voutsinas and Alexandra Nieters and {de Sanjose}, Silvia and Wendy Cozen and Alarc{\'o}n, {Graciela S} and Otoniel Martinez-Maza and Brown, {Elizabeth E} and Bracci, {Paige M} and Tracy Lightfoot and Jennifer Turner and Henrik Hjalgrim and Spinelli, {John J} and Tongzhang Zheng and Morton, {Lindsay M} and Birmann, {Brenda M} and Flowers, {Christopher R} and Ora Paltiel and Nikolaus Becker and Holly, {Elizabeth A} and Eleanor Kane and Dennis Weisenburger and Marc Maynadie and Pierluigi Cocco and Lenka Foretova and Anthony Staines and Scott Davis and Richard Severson and Cerhan, {James R} and Breen, {Elizabeth C} and Qing Lan and Angela Brooks-Wilson and {De Roos}, {Anneclaire J} and Smith, {Martyn T} and Eve Roman and Paolo Boffetta and Anne Kricker and Yawei Zhang and Christine Skibola and Chanock, {Stephen J} and Nathaniel Rothman and Yolanda Benavente and Patricia Hartge and Smedby, {Karin E}",

note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2015",

month = mar,

doi = "10.1093/aje/kwu290",

language = "English",

volume = "181",

journal = "American Journal of Epidemiology",

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Wang, SS, Vajdic, CM, Linet, MS, Slager, SL, Voutsinas, J, Nieters, A, de Sanjose, S, Cozen, W, Alarcón, GS, Martinez-Maza, O, Brown, EE, Bracci, PM, Lightfoot, T, Turner, J, Hjalgrim, H, Spinelli, JJ, Zheng, T, Morton, LM, Birmann, BM, Flowers, CR, Paltiel, O, Becker, N, Holly, EA, Kane, E, Weisenburger, D, Maynadie, M, Cocco, P, Foretova, L, Staines, A, Davis, S, Severson, R, Cerhan, JR, Breen, EC, Lan, Q, Brooks-Wilson, A, De Roos, AJ, Smith, MT, Roman, E, Boffetta, P, Kricker, A, Zhang, Y, Skibola, C, Chanock, SJ, Rothman, N, Benavente, Y, Hartge, P & Smedby, KE 2015, 'Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci', American Journal of Epidemiology, vol. 181, no. 6. https://doi.org/10.1093/aje/kwu290

TY - JOUR

T1 - Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci

AU - Wang, Sophia S

AU - Vajdic, Claire M

AU - Linet, Martha S

AU - Slager, Susan L

AU - Voutsinas, Jenna

AU - Nieters, Alexandra

AU - de Sanjose, Silvia

AU - Cozen, Wendy

AU - Alarcón, Graciela S

AU - Martinez-Maza, Otoniel

AU - Brown, Elizabeth E

AU - Bracci, Paige M

AU - Lightfoot, Tracy

AU - Turner, Jennifer

AU - Hjalgrim, Henrik

AU - Spinelli, John J

AU - Zheng, Tongzhang

AU - Morton, Lindsay M

AU - Birmann, Brenda M

AU - Flowers, Christopher R

AU - Paltiel, Ora

AU - Becker, Nikolaus

AU - Holly, Elizabeth A

AU - Kane, Eleanor

AU - Weisenburger, Dennis

AU - Maynadie, Marc

AU - Cocco, Pierluigi

AU - Foretova, Lenka

AU - Staines, Anthony

AU - Davis, Scott

AU - Severson, Richard

AU - Cerhan, James R

AU - Breen, Elizabeth C

AU - Lan, Qing

AU - Brooks-Wilson, Angela

AU - De Roos, Anneclaire J

AU - Smith, Martyn T

AU - Roman, Eve

AU - Boffetta, Paolo

AU - Kricker, Anne

AU - Zhang, Yawei

AU - Skibola, Christine

AU - Chanock, Stephen J

AU - Rothman, Nathaniel

AU - Benavente, Yolanda

AU - Hartge, Patricia

AU - Smedby, Karin E

PY - 2015/3

Y1 - 2015/3

N2 - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

AB - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

U2 - 10.1093/aje/kwu290

DO - 10.1093/aje/kwu290

M3 - Article

C2 - 25713336

SN - 0002-9262

VL - 181

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 6

ER -