By the same authors

From the same journal

From the same journal

Assuring the safety and effectiveness of new drugs: rigorous phase IV trials randomizing general practices to delayed access to new drugs

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalJournal of Health Services Research & Policy
DatePublished - Jan 2011
Issue number1
Volume17
Number of pages4
Pages (from-to)56-59
Original languageEnglish

Abstract

Randomized trials are crucial for establishing the effectiveness of new drugs and procedures. However, they are less effective at detecting uncommon but clinically significant side effects. We propose a solution. All UK general practices could be randomized to be allowed to prescribe new licenced drugs earlier or later. This would produce a large pragmatic cluster trial which could enable rare, but harmful, effects to be demonstrated more quickly than the current usual practice of looking for harmful events in observational datasets. Given current computerization of practice records such an approach is feasible and likely to be cost-effective.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations