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Astrocytic transporters in Alzheimer's disease

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Publication details

JournalBiochemical journal
DatePublished - 1 Feb 2017
Issue number3
Volume474
Number of pages23
Pages (from-to)333-355
Original languageEnglish

Abstract

Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, including Alzheimer's disease (AD). These changes may reflect a change from a neuroprotective to a neurotoxic phenotype. Given the lack of current disease-modifying therapies for AD, astrocytes have become an interesting and viable target for therapeutic intervention. The astrocyte transport system covers a diverse array of proteins involved in metabolic support, neurotransmission and synaptic architecture. Therefore, specific targeting of individual transporter families has the potential to suppress neurodegeneration, a characteristic hallmark of AD. A small number of the 400 transporter superfamilies are expressed in astrocytes, with evidence highlighting a fraction of these are implicated in AD. Here, we review the current evidence for six astrocytic transporter subfamilies involved in AD, as reported in both animal and human studies. This review confirms that astrocytes are indeed a viable target, highlights the complexities of studying astrocytes and provides future directives to exploit the potential of astrocytes in tackling AD.

    Research areas

  • ATP-Binding Cassette Transporters, Alzheimer Disease, Animals, Astrocytes, GABA Plasma Membrane Transport Proteins, Gene Expression Regulation, Glucose Transport Proteins, Facilitative, Glutamate Plasma Membrane Transport Proteins, Glycine Plasma Membrane Transport Proteins, Humans, Membrane Transport Proteins, Multigene Family, Serotonin Plasma Membrane Transport Proteins, Signal Transduction, Sodium-Potassium-Exchanging ATPase, Journal Article, Review, Research Support, Non-U.S. Gov't

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