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Asymmetric Assembling of Iron Oxide Nanocubes for Improving Magnetic Hyperthermia Performance

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Author(s)

  • Dina Niculaes
  • Aidin Lak
  • George C. Anyfantis
  • Sergio Marras
  • Oliver Laslett
  • Sahitya K. Avugadda
  • Marco Cassani
  • David Serantes
  • Ondrej Hovorka
  • Roy Chantrell
  • Teresa Pellegrino

Department/unit(s)

Publication details

JournalACS Nano
DateAccepted/In press - 20 Nov 2017
DateE-pub ahead of print - 20 Nov 2017
DatePublished (current) - 26 Dec 2017
Issue number12
Volume11
Number of pages13
Pages (from-to)12121-12133
Early online date20/11/17
Original languageEnglish

Abstract

Magnetic hyperthermia (MH) based on magnetic nanoparticles (MNPs) is a promising adjuvant therapy for cancer treatment. Particle clustering leading to complex magnetic interactions affects the heat generated by MNPs during MH. The heat efficiencies, theoretically predicted, are still poorly understood because of a lack of control of the fabrication of such clusters with defined geometries and thus their functionality. This study aims to correlate the heating efficiency under MH of individually coated iron oxide nanocubes (IONCs) versus soft colloidal nanoclusters made of small groupings of nanocubes arranged in different geometries. The controlled clustering of alkyl-stabilized IONCs is achieved here during the water transfer procedure by tuning the fraction of the amphiphilic copolymer, poly(styrene-co-maleic anhydride) cumene-terminated, to the nanoparticle surface. It is found that increasing the polymer-to-nanoparticle surface ratio leads to the formation of increasingly large nanoclusters with defined geometries. When compared to the individual nanocubes, we show here that controlled grouping of nanoparticles - so-called "dimers" and "trimers" composed of two and three nanocubes, respectively - increases specific absorption rate (SAR) values, while conversely, forming centrosymmetric clusters having more than four nanocubes leads to lower SAR values. Magnetization measurements and Monte Carlo-based simulations support the observed SAR trend and reveal the importance of the dipolar interaction effect and its dependence on the details of the particle arrangements within the different clusters.

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© 2017 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

    Research areas

  • annealing, controlled colloidal clustering, iron oxide nanocubes, magnetic hyperthermia, Monte Carlo simulation, poly(styrene-co-maleic anhydride), specific absorption rate

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