Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects

Darren Stead, Giorgio Carbone, Peter O'Brien, Kevin R. Campos, Iain Coldham, Adam Sanderson

Research output: Contribution to journalArticlepeer-review

Abstract

The high yielding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and a (+)-sparteine surrogate. Monitoring of the lithiation by in situ React IR allowed the direct observation of a prelithiation complex.

Original languageEnglish
Pages (from-to)7260-7261
JournalJournal of the American Chemical Society
Volume132
Issue number21
DOIs
Publication statusPublished - 2 Jun 2010

Keywords

  • LITHIATION
  • PYRROLIDINE
  • COMPLEX

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