Asymmetric Deprotonation using s-BuLi or i-PrLi and Chiral Diamines in THF: The Diamine Matters

Giorgio Carbone, Peter O'Brien, Goran Hilmersson

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Abstract

The solution structures of [Li-6]-i-PrLi complexed to (-)-sparteine and the (+)-sparteine surrogate in Et2O-d(10) and THF-d(8) at -80 degrees C have been determined using Li-6 and C-13 NMR spectroscopy. In Et2O, i-PrLi/(-)-sparteine is a solvent-complexed heterodimer, whereas i-PrLi/(+)-sparteine surrogate is a head-to-tail homodimer. In THF, there was no complexation of (-)-sparteine to i-PrLi until >= 3.0 equiv (-)-sparteine and with 6.0 equiv (-)-sparteine, a monomer was characterized. In contrast, the (+)-sparteine surrogate readily complexed to i-PrLi in THF, and with 1.0 equiv (+)-sparteine surrogate, complete formation of a monomer was observed. The NMR spectroscopic study suggested that it should be possible to carry out highly enantioselective asymmetric deprotonation reactions using i-PrLi or s-BuLi/(+)-sparteine surrogate in THF. Hence, three different asymmetric deprotonation reactions (lithiation-trapping of N-Boc pyrrolidine, an O-alkyl carbamate, and a phosphine borane) were investigated; it was shown that reactions with (-)-sparteine in THF proceeded with low enantioselectivity, whereas the corresponding reactions with the (+)-sparteine surrogate occurred with high enantioselectivity. These are the first examples of highly enantioselective asymmetric deprotonation reactions using organolithium/diamine complexes in THF.

Original languageEnglish
Pages (from-to)15445-15450
Number of pages6
JournalJournal of the American Chemical Society
Volume132
Issue number43
DOIs
Publication statusPublished - 3 Nov 2010

Keywords

  • ENANTIOSELECTIVE SYNTHESES
  • (+)-SPARTEINE SURROGATE
  • ORGANOLITHIUM COMPOUNDS
  • CRYSTAL-STRUCTURES
  • ALPHA-LITHIATION
  • PHENYLLITHIUM
  • BUTYLLITHIUM
  • SUBSTITUTION
  • PYRROLIDINE
  • REACTIVITY

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