Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

T M Gloster, S J Williams, S Roberts, C A Tarling, J Wicki, S G Withers, G J Davies

Research output: Contribution to journalArticlepeer-review

Abstract

The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

Original languageEnglish
Pages (from-to)1794-1795
Number of pages2
JournalChemical Communications
Issue number16
DOIs
Publication statusPublished - 2004

Keywords

  • GLYCOSIDASE INHIBITOR
  • STATE

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