From the same journal

From the same journal

From the same journal

Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins

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Author(s)

  • W.M. Gray
  • O. Leyser
  • M. Estelle
  • S. Kepinski
  • D. Rouse

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Publication details

JournalNature
DatePublished - 15 Nov 2001
Issue number6861
Volume414
Number of pages5
Pages (from-to)271-276
Original languageEnglish

Abstract

The plant hormone auxin is central in many aspects of plant development. Previous studies have implicated the ubiquitin-ligase SCFTIR1 and the AUX/IAA proteins in auxin response. Dominant mutations in several AUX/IAA genes confer pleiotropic auxin-related phenotypes, whereas recessive mutations affecting the function of SCFTIR1 decrease auxin response. Here we show that SCFTIR1 is required for AUX/IAA degradation. We demonstrate that SCFTIR1 interacts with AXR2/IAA7 and AXR3/IAA17, and that domain II of these proteins is necessary and sufficient for this interaction. Further, auxin stimulates binding of SCFTIR1 to the AUX/IAA proteins, and their degradation. Because domain II is conserved in nearly all AUX/IAA proteins in Arabidopsis, we propose that auxin promotes the degradation of this large family of transcriptional regulators, leading to diverse downstream effects.

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© 2001 Macmillan Magazines Ltd

    Research areas

  • SCF UBIQUITIN-LIGASE, ARABIDOPSIS-THALIANA, RESPONSE ELEMENTS, GENE, YEAST, TRANSCRIPTION, PATHWAY, FAMILY, NEDD8, RUB1

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