Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input

M Griffin; D M Halliday

doi:10.1016/j.neucom.2004.01.076

Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input

M Griffin
, D M Halliday

Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	423-430
Number of pages	8
Journal	Neurocomputing
Volume	58-60
DOIs	https://doi.org/10.1016/j.neucom.2004.01.076
Publication status	Published - Jun 2004

Keywords

synaptic integration
axial current
temporal coding
dendrites
compartmental model
IDENTIFIED ALPHA-MOTONEURONS
BACKGROUND ACTIVITY
CABLE PROPERTIES
ARCHITECTURE
INTEGRATION
NEURON
CELLS

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10.1016/j.neucom.2004.01.076

Cite this

@article{5a33e42a83af492c98b0f68b27cba06d,

title = "Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input",

abstract = "We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.",

keywords = "synaptic integration, axial current, temporal coding, dendrites, compartmental model, IDENTIFIED ALPHA-MOTONEURONS, BACKGROUND ACTIVITY, CABLE PROPERTIES, ARCHITECTURE, INTEGRATION, NEURON, CELLS",

author = "M Griffin and Halliday, \{D M\}",

year = "2004",

month = jun,

doi = "10.1016/j.neucom.2004.01.076",

language = "English",

volume = "58-60",

pages = "423--430",

journal = "Neurocomputing",

issn = "0925-2312",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input

AU - Griffin, M

AU - Halliday, D M

PY - 2004/6

Y1 - 2004/6

N2 - We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.

AB - We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.

KW - synaptic integration

KW - axial current

KW - temporal coding

KW - dendrites

KW - compartmental model

KW - IDENTIFIED ALPHA-MOTONEURONS

KW - BACKGROUND ACTIVITY

KW - CABLE PROPERTIES

KW - ARCHITECTURE

KW - INTEGRATION

KW - NEURON

KW - CELLS

U2 - 10.1016/j.neucom.2004.01.076

DO - 10.1016/j.neucom.2004.01.076

M3 - Article

SN - 0925-2312

VL - 58-60

SP - 423

EP - 430

JO - Neurocomputing

JF - Neurocomputing

ER -