Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input

M Griffin; D M Halliday

Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input

Electronic Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.

Original language	English
Title of host publication	COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH 2004
Editors	E DeSchutter
Place of Publication	AMSTERDAM
Publisher	Elsevier
Pages	423-430
Number of pages	8
ISBN (Print)	0-444-51649-2
Publication status	Published - 2004
Event	12th Annual Computational Neuroscience Meeting (CNS 03) - Alicante Duration: 5 Jul 2003 → 9 Jul 2003

Conference

Conference	12th Annual Computational Neuroscience Meeting (CNS 03)
City	Alicante
Period	5/07/03 → 9/07/03

Keywords

synaptic integration
axial current
temporal coding
dendrites
compartmental model
IDENTIFIED ALPHA-MOTONEURONS
BACKGROUND ACTIVITY
CABLE PROPERTIES
ARCHITECTURE
INTEGRATION
CELLS

Cite this

@inproceedings{283dc3c2903f4471b23ce08657f8a6c4,

title = "Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input",

abstract = "We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.",

keywords = "synaptic integration, axial current, temporal coding, dendrites, compartmental model, IDENTIFIED ALPHA-MOTONEURONS, BACKGROUND ACTIVITY, CABLE PROPERTIES, ARCHITECTURE, INTEGRATION, CELLS",

author = "M Griffin and Halliday, {D M}",

year = "2004",

language = "English",

isbn = "0-444-51649-2",

pages = "423--430",

editor = "E DeSchutter",

booktitle = "COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH 2004",

publisher = "Elsevier",

address = "Netherlands",

note = "12th Annual Computational Neuroscience Meeting (CNS 03) ; Conference date: 05-07-2003 Through 09-07-2003",

}

TY - GEN

T1 - Axial current reversal promotes synchronous correlation between dendritic membrane potentials during large-scale synaptic input

AU - Griffin, M

AU - Halliday, D M

PY - 2004

Y1 - 2004

N2 - We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.

AB - We report two results from a simulation study of spatial temporal interactions in a dendritic tree during large-scale synaptic input. The first is a feedback mechanism following individual synaptic inputs, which results in a reversal of the axial current 1-2 ms after activation of an input. The second is a time domain transfer function analysis between the membrane potential fluctuations at different sites. During large-scale synaptic input, this has a symmetrical structure, indicative of a two-way flow of axial current in the dendritic tree. We interpret this as an indication of a synchronous correlation structure between membrane potential fluctuations during large-scale synaptic input, which may have implications for our understanding of synaptic integration. (C) 2004 Elsevier B.V. All rights reserved.

KW - synaptic integration

KW - axial current

KW - temporal coding

KW - dendrites

KW - compartmental model

KW - IDENTIFIED ALPHA-MOTONEURONS

KW - BACKGROUND ACTIVITY

KW - CABLE PROPERTIES

KW - ARCHITECTURE

KW - INTEGRATION

KW - CELLS

M3 - Conference contribution

SN - 0-444-51649-2

SP - 423

EP - 430

BT - COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH 2004

A2 - DeSchutter, E

PB - Elsevier

CY - AMSTERDAM

T2 - 12th Annual Computational Neuroscience Meeting (CNS 03)

Y2 - 5 July 2003 through 9 July 2003

ER -