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Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP

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JournalBiomolecular NMR assignments
DateE-pub ahead of print - 9 Aug 2012
DatePublished (current) - Oct 2013
Issue number2
Volume7
Number of pages5
Pages (from-to)229-233
Early online date9/08/12
Original languageEnglish

Abstract

TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.

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