By the same authors

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Bacterial and eukaryotic systems collide in the three Rs of Methanococcus

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Publication details

JournalBiochemical Society transactions
DatePublished - Feb 2011
Issue number1
Number of pages5
Pages (from-to)111-5
Original languageEnglish


Methanococcus maripaludis S2 is a methanogenic archaeon with a well-developed genetic system. Its mesophilic nature offers a simple system in which to perform complementation using bacterial and eukaryotic genes. Although information-processing systems in archaea are generally more similar to those in eukaryotes than those in bacteria, the order Methanococcales has a unique complement of DNA replication proteins, with multiple MCM (minichromosome maintenance) proteins and no obvious originbinding protein. A search for homologues of recombination and repair proteins in M. maripaludis has revealed a mixture of bacterial, eukaryotic and some archaeal-specific homologues. Some repair pathways appear to be completely absent, but it is possible that archaeal-specific proteins could carry out these functions. The replication, recombination and repair systems in M. maripaludis are an interesting mixture of eukaryotic and bacterial homologues and could provide a system for uncovering novel interactions between proteins from different domains of life.

    Research areas

  • Archaeal Proteins, Bacterial Proteins, Base Pair Mismatch, DNA Repair, DNA Replication, Eukaryota, Methanococcus, Molecular Sequence Data, Recombination, Genetic

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