By the same authors

Baculoviruses as vectors for gene therapy against human prostate cancer

Research output: Contribution to journalLiterature review

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JournalJournal of biomedicine and biotechnology
DatePublished - 21 Apr 2003
Issue number2
Volume2003
Number of pages13
Pages (from-to)79-91
Original languageEnglish

Abstract

Current curative strategies for prostate cancer are restricted to the primary turnout, and the effect of treatments to control metastatic disease is not sustained. Therefore, the application of gene therapy to prostate cancer is an attractive alternative. Baculoviruses are highly restricted insect viruses, which can enter, but not replicate in mammalian cells. Baculoviruses can incorporate large amounts of extra genetic material, and will express transgenes in mammalian cells when under the control of a mammalian or strong viral promoter. Successful gene delivery has been achieved both in vitro and in vivo and into both dividing and nondividing cells, which is important since prostate cancers divide relatively slowly. In addition, the envelope protein gp64 is sufficiently mutable to allow targeted transduction of particular cell types. In this review, the advantages of using baculoviruses for prostate cancer gene therapy are explored, and the mechanisms of viral entry and transgene expression are described.

    Research areas

  • NUCLEAR POLYHEDROSIS-VIRUS, MAMMALIAN-CELLS, RECOMBINANT BACULOVIRUS, COMPLEMENT-SYSTEM, ANTIGEN PROMOTER, EFFICIENT TRANSDUCTION, EXPRESSION PROFILE, ADENOVIRAL VECTOR, RNA-POLYMERASES, IN-VITRO

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