Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

Jannik Stemler; Caroline Bruns; Sibylle C Mellinghoff; Nael Alakel; Hamdi Akan; Michelle Ananda-Rajah; Jutta Auberger; Peter Bojko; Pranatharthi H Chandrasekar; Methee Chayakulkeeree; José A Cozzi; Elizabeth A de Kort; Andreas H Groll; Christopher H Heath; Larissa Henze; Marcos Hernandez Jimenez; Souha S Kanj; Nina Khanna; Michael Koldehoff; Dong-Gun Lee; Alina Mager; Francesco Marchesi; Rodrigo Martino-Bufarull; Marcio Nucci; Jarmo Oksi; Livio Pagano; Bob Phillips; Juergen Prattes; Athina Pyrpasopoulou; Werner Rabitsch; Enrico Schalk; Martin Schmidt-Hieber; Neeraj Sidharthan; Pere Soler-Palacín; Anat Stern; Barbora Weinbergerová; Aline El Zakhem; Oliver A Cornely; Philipp Koehler

doi:10.3390/jof6010036

Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

Jannik Stemler, Caroline Bruns, Sibylle C Mellinghoff, Nael Alakel, Hamdi Akan, Michelle Ananda-Rajah, Jutta Auberger, Peter Bojko, Pranatharthi H Chandrasekar, Methee Chayakulkeeree, José A Cozzi, Elizabeth A de Kort, Andreas H Groll, Christopher H Heath, Larissa Henze, Marcos Hernandez Jimenez, Souha S Kanj, Nina Khanna, Michael Koldehoff, Dong-Gun LeeAlina Mager, Francesco Marchesi, Rodrigo Martino-Bufarull, Marcio Nucci, Jarmo Oksi, Livio Pagano, Bob Phillips, Juergen Prattes, Athina Pyrpasopoulou, Werner Rabitsch, Enrico Schalk, Martin Schmidt-Hieber, Neeraj Sidharthan, Pere Soler-Palacín, Anat Stern, Barbora Weinbergerová, Aline El Zakhem, Oliver A Cornely, Philipp Koehler

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Abstract

Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Journal of fungi (Basel, Switzerland)
Volume	6
Issue number	1
DOIs	https://doi.org/10.3390/jof6010036
Publication status	Published - 13 Mar 2020

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jof-06-00036
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Cite this

Stemler, J., Bruns, C., Mellinghoff, S. C., Alakel, N., Akan, H., Ananda-Rajah, M., Auberger, J., Bojko, P., Chandrasekar, P. H., Chayakulkeeree, M., Cozzi, J. A., de Kort, E. A., Groll, A. H., Heath, C. H., Henze, L., Hernandez Jimenez, M., Kanj, S. S., Khanna, N., Koldehoff, M., ... Koehler, P. (2020). Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients. Journal of fungi (Basel, Switzerland), 6(1), 1-12. https://doi.org/10.3390/jof6010036

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title = "Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients",

abstract = "Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.",

author = "Jannik Stemler and Caroline Bruns and Mellinghoff, {Sibylle C} and Nael Alakel and Hamdi Akan and Michelle Ananda-Rajah and Jutta Auberger and Peter Bojko and Chandrasekar, {Pranatharthi H} and Methee Chayakulkeeree and Cozzi, {Jos{\'e} A} and {de Kort}, {Elizabeth A} and Groll, {Andreas H} and Heath, {Christopher H} and Larissa Henze and {Hernandez Jimenez}, Marcos and Kanj, {Souha S} and Nina Khanna and Michael Koldehoff and Dong-Gun Lee and Alina Mager and Francesco Marchesi and Rodrigo Martino-Bufarull and Marcio Nucci and Jarmo Oksi and Livio Pagano and Bob Phillips and Juergen Prattes and Athina Pyrpasopoulou and Werner Rabitsch and Enrico Schalk and Martin Schmidt-Hieber and Neeraj Sidharthan and Pere Soler-Palac{\'i}n and Anat Stern and Barbora Weinbergerov{\'a} and {El Zakhem}, Aline and Cornely, {Oliver A} and Philipp Koehler",

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doi = "10.3390/jof6010036",

language = "English",

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Stemler, J, Bruns, C, Mellinghoff, SC, Alakel, N, Akan, H, Ananda-Rajah, M, Auberger, J, Bojko, P, Chandrasekar, PH, Chayakulkeeree, M, Cozzi, JA, de Kort, EA, Groll, AH, Heath, CH, Henze, L, Hernandez Jimenez, M, Kanj, SS, Khanna, N, Koldehoff, M, Lee, D-G, Mager, A, Marchesi, F, Martino-Bufarull, R, Nucci, M, Oksi, J, Pagano, L, Phillips, B, Prattes, J, Pyrpasopoulou, A, Rabitsch, W, Schalk, E, Schmidt-Hieber, M, Sidharthan, N, Soler-Palacín, P, Stern, A, Weinbergerová, B, El Zakhem, A, Cornely, OA & Koehler, P 2020, 'Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients', Journal of fungi (Basel, Switzerland), vol. 6, no. 1, pp. 1-12. https://doi.org/10.3390/jof6010036

TY - JOUR

T1 - Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

AU - Stemler, Jannik

AU - Bruns, Caroline

AU - Mellinghoff, Sibylle C

AU - Alakel, Nael

AU - Akan, Hamdi

AU - Ananda-Rajah, Michelle

AU - Auberger, Jutta

AU - Bojko, Peter

AU - Chandrasekar, Pranatharthi H

AU - Chayakulkeeree, Methee

AU - Cozzi, José A

AU - de Kort, Elizabeth A

AU - Groll, Andreas H

AU - Heath, Christopher H

AU - Henze, Larissa

AU - Hernandez Jimenez, Marcos

AU - Kanj, Souha S

AU - Khanna, Nina

AU - Koldehoff, Michael

AU - Lee, Dong-Gun

AU - Mager, Alina

AU - Marchesi, Francesco

AU - Martino-Bufarull, Rodrigo

AU - Nucci, Marcio

AU - Oksi, Jarmo

AU - Pagano, Livio

AU - Phillips, Bob

AU - Prattes, Juergen

AU - Pyrpasopoulou, Athina

AU - Rabitsch, Werner

AU - Schalk, Enrico

AU - Schmidt-Hieber, Martin

AU - Sidharthan, Neeraj

AU - Soler-Palacín, Pere

AU - Stern, Anat

AU - Weinbergerová, Barbora

AU - El Zakhem, Aline

AU - Cornely, Oliver A

AU - Koehler, Philipp

PY - 2020/3/13

Y1 - 2020/3/13

N2 - Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.

AB - Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.

U2 - 10.3390/jof6010036

DO - 10.3390/jof6010036

M3 - Article

C2 - 32183235

SN - 2309-608X

VL - 6

SP - 1

EP - 12

JO - Journal of fungi (Basel, Switzerland)

JF - Journal of fungi (Basel, Switzerland)

IS - 1

ER -