By the same authors

From the same journal

From the same journal

BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas

Research output: Contribution to journalArticle

Author(s)

  • S Gill
  • J Broni
  • S Jefferies
  • P Osin
  • G Kovacs
  • N J Maitland
  • R Eeles
  • S M Edwards
  • M J S Dyer
  • T G Willis
  • C S Cooper
  • MPT Collaborators, St Georges Hosp Collaborators

Department/unit(s)

Publication details

JournalBritish journal of cancer
DatePublished - Jul 1999
Issue number10
Volume80
Number of pages4
Pages (from-to)1565-1568
Original languageEnglish

Abstract

We have used single-strand conformation polymorphism (SSCP) analysis to screen for mutations in the BCL10 gene in 81 primary prostate carcinomas, 20 squamous cell cancers of the head and neck, 15 small-cell lung cancer cell lines, 24 renal carcinoma cell lines and 13 sarcoma cell lines. We failed to find evidence of somatically acquired mutations of the BCL10 gene suggesting that BCL10 does not play a major role in the development of these malignancies.

    Research areas

  • BCL10, mutation, prostate cancer, sarcomas, lung cancer, renal carcinoma, head and neck squamous cell cancers, GENE, LYMPHOMA, LINE, P53

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