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From the same journal

Benefits of automated crystallization plate tracking, imaging, and analysis

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Ian Berry
  • Jonathan Diprose
  • Robert Esnouf
  • Karl Harlos
  • E. Yvonne Jones
  • Christopher Mayo
  • Ray Owens
  • David Stuart
  • Thomas Walter
  • Julie C. Wilson

Department/unit(s)

Publication details

JournalStructure
DatePublished - Feb 2005
Issue number2
Volume13
Number of pages8
Pages (from-to)175-182
Original languageEnglish

Abstract

We describe the design of a database and software for managing and organizing protein crystallization data. We also outline the considerations behind the design of a fast web interface linking protein production data, crystallization images, and automated image analysis. The database and associated interfaces underpin the Oxford Protein Production Facility (OPPF) crystallization laboratory, collecting, in a routine and automatic manner, up to 100,000 images per day. Over 17 million separate images are currently held in this database. We discuss the substantial scientific benefits automated tracking, imaging, and analysis of crystallizations offers to the structural biologist: analysis of the time course of the trial and easy analysis of trials with related crystallization conditions. Features of this system address requirements common to many crystallographic laboratories that are currently setting up (semi-)automated crystallization imaging systems.

    Research areas

  • THERMOTOGA-MARITIMA PROTEOME, STRUCTURAL GENOMICS, PIPELINE

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