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Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network

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Author(s)

  • Lourdes Cucurull-Sanchez
  • Michael J Chappell
  • Vijayalakshmi Chelliah
  • S Y Amy Cheung
  • Gianne Derks
  • Mark Penney
  • Alex Phipps
  • Rahuman S Malik-Sheriff
  • Jon Timmis
  • Marcus J Tindall
  • Piet H van der Graaf
  • Paolo Vicini
  • James W T Yates

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Publication details

JournalCPT Pharmacometrics & Systems Pharmacology
DateAccepted/In press - 17 Dec 2018
DateE-pub ahead of print (current) - 22 Jan 2019
Early online date22/01/19
Original languageEnglish

Abstract

The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermines the potential impact of QSP in academic, industrial, and regulatory frameworks. This article presents a minimum set of recommendations from the UK Quantitative and Systems Pharmacology Network (UK QSP Network) to guide QSP practitioners seeking to maximize their impact, and stakeholders considering the use of QSP models in their environment.

Bibliographical note

© 2019 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

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