beta-selective epoxidation of Delta(5)-steroids by O-2 using surface functionalised silica supported cobalt catalysts

S M  Silvestre; J A R  Salvador; J H  Clark

doi:10.1016/j.molcata.2004.04.034

beta-selective epoxidation of Delta(5)-steroids by O-2 using surface functionalised silica supported cobalt catalysts

S M Silvestre, J A R Salvador, J H Clark

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A general catalytic and relatively environment friendly method for beta-epoxidation of Delta(5)-steroids has been developed, which uses silica supported cobalt as catalysts and molecular oxygen as the oxidant. The reactions are regio- and stereoselective.

A whole range of Delta(5)-steroids, with different functional groups such as hydroxyl, carbonyl or acetyl, as well as different side chains, were conveniently converted to the corresponding biologically interesting 5beta,6beta-epoxides with high degree of stereoselectivity and high yields. (C) 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	Journal of Molecular Catalysis A: Chemical
Volume	219
Issue number	1
DOIs	https://doi.org/10.1016/j.molcata.2004.04.034
Publication status	Published - 1 Sept 2004

Keywords

Delta(5)-steroids
oxygen
cobalt heterogeneous catalysts
5 beta,6 beta-epoxides
POTASSIUM-PERMANGANATE
DELTA(5)-UNSATURATED STEROIDS
UNSATURATED STEROIDS
CONVENIENT SYNTHESIS
AEROBIC EPOXIDATION
MOLECULAR-OXYGEN
METAL-CATALYSTS
OXIDATION
ION
STEREOCHEMISTRY

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10.1016/j.molcata.2004.04.034

Cite this

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title = "beta-selective epoxidation of Delta(5)-steroids by O-2 using surface functionalised silica supported cobalt catalysts",

abstract = "A general catalytic and relatively environment friendly method for beta-epoxidation of Delta(5)-steroids has been developed, which uses silica supported cobalt as catalysts and molecular oxygen as the oxidant. The reactions are regio- and stereoselective.A whole range of Delta(5)-steroids, with different functional groups such as hydroxyl, carbonyl or acetyl, as well as different side chains, were conveniently converted to the corresponding biologically interesting 5beta,6beta-epoxides with high degree of stereoselectivity and high yields. (C) 2004 Elsevier B.V. All rights reserved.",

keywords = "Delta(5)-steroids, oxygen, cobalt heterogeneous catalysts, 5 beta,6 beta-epoxides, POTASSIUM-PERMANGANATE, DELTA(5)-UNSATURATED STEROIDS, UNSATURATED STEROIDS, CONVENIENT SYNTHESIS, AEROBIC EPOXIDATION, MOLECULAR-OXYGEN, METAL-CATALYSTS, OXIDATION, ION, STEREOCHEMISTRY",

author = "Silvestre, {S M} and Salvador, {J A R} and Clark, {J H}",

year = "2004",

month = sep,

day = "1",

doi = "10.1016/j.molcata.2004.04.034",

language = "English",

volume = "219",

pages = "143--147",

journal = "Journal of Molecular Catalysis A: Chemical",

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TY - JOUR

T1 - beta-selective epoxidation of Delta(5)-steroids by O-2 using surface functionalised silica supported cobalt catalysts

AU - Silvestre, S M

AU - Salvador, J A R

AU - Clark, J H

PY - 2004/9/1

Y1 - 2004/9/1

N2 - A general catalytic and relatively environment friendly method for beta-epoxidation of Delta(5)-steroids has been developed, which uses silica supported cobalt as catalysts and molecular oxygen as the oxidant. The reactions are regio- and stereoselective.A whole range of Delta(5)-steroids, with different functional groups such as hydroxyl, carbonyl or acetyl, as well as different side chains, were conveniently converted to the corresponding biologically interesting 5beta,6beta-epoxides with high degree of stereoselectivity and high yields. (C) 2004 Elsevier B.V. All rights reserved.

AB - A general catalytic and relatively environment friendly method for beta-epoxidation of Delta(5)-steroids has been developed, which uses silica supported cobalt as catalysts and molecular oxygen as the oxidant. The reactions are regio- and stereoselective.A whole range of Delta(5)-steroids, with different functional groups such as hydroxyl, carbonyl or acetyl, as well as different side chains, were conveniently converted to the corresponding biologically interesting 5beta,6beta-epoxides with high degree of stereoselectivity and high yields. (C) 2004 Elsevier B.V. All rights reserved.

KW - Delta(5)-steroids

KW - oxygen

KW - cobalt heterogeneous catalysts

KW - 5 beta,6 beta-epoxides

KW - POTASSIUM-PERMANGANATE

KW - DELTA(5)-UNSATURATED STEROIDS

KW - UNSATURATED STEROIDS

KW - CONVENIENT SYNTHESIS

KW - AEROBIC EPOXIDATION

KW - MOLECULAR-OXYGEN

KW - METAL-CATALYSTS

KW - OXIDATION

KW - ION

KW - STEREOCHEMISTRY

U2 - 10.1016/j.molcata.2004.04.034

DO - 10.1016/j.molcata.2004.04.034

M3 - Article

SN - 1381-1169

VL - 219

SP - 143

EP - 147

JO - Journal of Molecular Catalysis A: Chemical

JF - Journal of Molecular Catalysis A: Chemical

IS - 1

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