Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications

Manuel González-Cuest; Peter Sidhu; Roger A. Ashmus; Alexandra Males; Cameron Proceviat; Zarina Madden; Jason C. Rogalski; Jil A. Busmann; Leonard J. Foster; José M. García Fernández; Gideon J. Davies; Carmen Ortiz Mellet; David J. Vocadlo

doi:10.1021/jacs.1c10504

Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications

Manuel González-Cuest, Peter Sidhu, Roger A. Ashmus, Alexandra Males, Cameron Proceviat, Zarina Madden, Jason C. Rogalski, Jil A. Busmann, Leonard J. Foster, José M. García Fernández, Gideon J. Davies, Carmen Ortiz Mellet, David J. Vocadlo

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	832–844
Number of pages	13
Journal	Journal of the American Chemical Society
Volume	144
Issue number	2
Early online date	5 Jan 2022
DOIs	https://doi.org/10.1021/jacs.1c10504
Publication status	Published - 19 Jan 2022

Bibliographical note

© 2022 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

Access to Document

10.1021/jacs.1c10504

Gonzalez-Cuesta-JACS
© 2022 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Accepted author manuscript, 10.1 MBLicence: Unspecified

1 Finished
1 Active

RS Research Professorship
Davies, G. J. (Principal investigator)
THE ROYAL SOCIETY
1/01/17 → 31/12/27
Project: Research project (funded) › Research
Dissection of the Leishmania mannogen biosynthetic pathway: beta 1-2 mannan in pathogens and beyond
Davies, G. J. (Principal investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
20/01/20 → 19/04/23
Project: Research project (funded) › Research

Cite this

González-Cuest, M., Sidhu, P., Ashmus, R. A., Males, A., Proceviat, C., Madden, Z., Rogalski, J. C., Busmann, J. A., Foster, L. J., Fernández, J. M. G., Davies, G. J., Mellet, C. O., & Vocadlo, D. J. (2022). Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications. Journal of the American Chemical Society, 144 (2), 832–844. https://doi.org/10.1021/jacs.1c10504

@article{5b9e8e98d387458a8d849f401429fef8,

title = "Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications",

author = "Manuel Gonz{\'a}lez-Cuest and Peter Sidhu and Ashmus, {Roger A.} and Alexandra Males and Cameron Proceviat and Zarina Madden and Rogalski, {Jason C.} and Busmann, {Jil A.} and Foster, {Leonard J.} and Fern{\'a}ndez, {Jos{\'e} M. Garc{\'i}a} and Davies, {Gideon J.} and Mellet, {Carmen Ortiz} and Vocadlo, {David J.}",

note = "{\textcopyright} 2022 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details",

year = "2022",

month = jan,

day = "19",

doi = "10.1021/jacs.1c10504",

language = "English",

volume = "144 ",

pages = "832–844",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "2",

}

González-Cuest, M, Sidhu, P, Ashmus, RA, Males, A, Proceviat, C, Madden, Z, Rogalski, JC, Busmann, JA, Foster, LJ, Fernández, JMG, Davies, GJ, Mellet, CO & Vocadlo, DJ 2022, 'Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications', Journal of the American Chemical Society, vol. 144 , no. 2, pp. 832–844. https://doi.org/10.1021/jacs.1c10504

TY - JOUR

T1 - Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications

AU - González-Cuest, Manuel

AU - Sidhu, Peter

AU - Ashmus, Roger A.

AU - Males, Alexandra

AU - Proceviat, Cameron

AU - Madden, Zarina

AU - Rogalski, Jason C.

AU - Busmann, Jil A.

AU - Foster, Leonard J.

AU - Fernández, José M. García

AU - Davies, Gideon J.

AU - Mellet, Carmen Ortiz

AU - Vocadlo, David J.

N1 - © 2022 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2022/1/19

Y1 - 2022/1/19

U2 - 10.1021/jacs.1c10504

DO - 10.1021/jacs.1c10504

M3 - Article

SN - 0002-7863

VL - 144

SP - 832

EP - 844

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 2

ER -

Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications

Bibliographical note

Access to Document

Projects

RS Research Professorship

Dissection of the Leishmania mannogen biosynthetic pathway: beta 1-2 mannan in pathogens and beyond

Cite this