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From the same journal

Biomarkers and brains: situating dementia in the laboratory and in the memory clinic

Research output: Contribution to journalArticle

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Publication details

JournalNew Genetics and Society
DateAccepted/In press - 31 Jul 2019
DateE-pub ahead of print (current) - 13 Aug 2019
Number of pages16
Pages (from-to)1-16
Early online date13/08/19
Original languageEnglish

Abstract

This paper provides a comparison of how genetic biomarkers are used (or not) in three contexts: clinic-based diagnostic work with people; lab-based research on mice and their marbles; and lab-based research on thrashing nematodes. For all the worldwide drive to find biomarkers that can be used in the detection of early, presymptomatic dementia, there is little research on how or when the association between biomarkers and a definitive disease are being made to “hold.” First, we show the disjuncture between the animal modeling that underpins laboratory attempts to stabilize genetic biomarkers and the paradigms that inform clinical diagnosis. Secondly, we develop this theme to show how in our third site, an epigenetics “worm” laboratory, neurodegenerative changes are explored as located in specific gene-environment interactions over time. We speculate whether such an enactment brings us closer to a notion of “situated biology,” to undercut possibilities of making genetic biomarkers of preclinical dementia hold.

Bibliographical note

© 2019 The Author(s)

    Research areas

  • animal models, biogerontology, dementia, epigenetics, memory clinics, mindedness

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