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Biophysics in drug discovery: impact, challenges and opportunities
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| Journal | Nature reviews. Drug discovery |
|---|---|
| Date | E-pub ahead of print - 12 Aug 2016 |
| Date | Published (current) - 12 Aug 2016 |
| Issue number | 10 |
| Volume | 15 |
| Number of pages | 20 |
| Pages (from-to) | 679-698 |
| Early online date | 12/08/16 |
| Original language | English |
Abstract
Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermal titration calorimetry have become key components of drug discovery platforms in many pharmaceutical companies and academic laboratories. There have been great improvements in the speed, sensitivity and range of possible measurements, providing high-resolution mechanistic, kinetic, thermodynamic and structural information on compound-target interactions. This Review provides a framework to understand this evolution by describing the key biophysical methods, the information they can provide and the ways in which they can be applied at different stages of the drug discovery process. We also discuss the challenges for current technologies and future opportunities to use biophysical methods to solve drug discovery problems.
Bibliographical note
© 2016, Macmillan publishers limited, part of Springer Nature.This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
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