Biophysics in drug discovery: impact, challenges and opportunities

Jean-Paul Renaud; Chun-Wa Chung; U Helena Danielson; Ursula Egner; Michael Hennig; Roderick E Hubbard; Herbert Nar

doi:10.1038/nrd.2016.123

Biophysics in drug discovery: impact, challenges and opportunities

Jean-Paul Renaud, Chun-Wa Chung, U Helena Danielson, Ursula Egner, Michael Hennig, Roderick E Hubbard, Herbert Nar

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermal titration calorimetry have become key components of drug discovery platforms in many pharmaceutical companies and academic laboratories. There have been great improvements in the speed, sensitivity and range of possible measurements, providing high-resolution mechanistic, kinetic, thermodynamic and structural information on compound-target interactions. This Review provides a framework to understand this evolution by describing the key biophysical methods, the information they can provide and the ways in which they can be applied at different stages of the drug discovery process. We also discuss the challenges for current technologies and future opportunities to use biophysical methods to solve drug discovery problems.

Original language	English
Pages (from-to)	679-698
Number of pages	20
Journal	Nature reviews. Drug discovery
Volume	15
Issue number	10
Early online date	12 Aug 2016
DOIs	https://doi.org/10.1038/nrd.2016.123
Publication status	Published - 12 Aug 2016

Bibliographical note

© 2016, Macmillan publishers limited, part of Springer Nature.This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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© 2016, Macmillan publishers limited, part of Springer Nature.This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
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Cite this

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abstract = "Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermal titration calorimetry have become key components of drug discovery platforms in many pharmaceutical companies and academic laboratories. There have been great improvements in the speed, sensitivity and range of possible measurements, providing high-resolution mechanistic, kinetic, thermodynamic and structural information on compound-target interactions. This Review provides a framework to understand this evolution by describing the key biophysical methods, the information they can provide and the ways in which they can be applied at different stages of the drug discovery process. We also discuss the challenges for current technologies and future opportunities to use biophysical methods to solve drug discovery problems.",

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AU - Hubbard, Roderick E

AU - Nar, Herbert

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