Bladder tissue regeneration

S. C. Baker; J. Southgate

doi:10.1016/B978-1-84569-741-9.50011-2

Bladder tissue regeneration

S. C. Baker, J. Southgate^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

organ donor shortages have driven the search for tissue engineering and regenerative solutions in many tissue pathologies, but disorders of the urinary bladder have no allograft solution. Currently, end-stage bladder disease is addressed by reconstructing the bladder with vascularised segments of bowel, but serious long-term side-effects correspond to a clinical need to develop new approaches. the application of electrospun biomaterials, in combination with in vitro tissue engineering or in vivo regenerative engineering strategies, holds elusive promise for routine bladder augmentation or substitution. The major challenges include identification of suitable elastic/biodegradable polymers and scaffold architectures that match the physical and biological requirements of the bladder.

Original language	English
Title of host publication	Electrospinning for Tissue Regeneration
Publisher	Elsevier
Pages	225-241
Number of pages	17
ISBN (Print)	9781845697419
DOIs	https://doi.org/10.1016/B978-1-84569-741-9.50011-2
Publication status	Published - Jun 2011

Bibliographical note

Funding Information:
The authors thank Felix Wezel for critical review of the manuscript. Jennifer Southgate is supported by York Against Cancer.

Keywords

Bladder biomaterial
Bladder regeneration
Electrospun polystyrene
Urinary tract tissue engineering
Urothelium

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10.1016/B978-1-84569-741-9.50011-2

Cite this

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title = "Bladder tissue regeneration",

abstract = "organ donor shortages have driven the search for tissue engineering and regenerative solutions in many tissue pathologies, but disorders of the urinary bladder have no allograft solution. Currently, end-stage bladder disease is addressed by reconstructing the bladder with vascularised segments of bowel, but serious long-term side-effects correspond to a clinical need to develop new approaches. the application of electrospun biomaterials, in combination with in vitro tissue engineering or in vivo regenerative engineering strategies, holds elusive promise for routine bladder augmentation or substitution. The major challenges include identification of suitable elastic/biodegradable polymers and scaffold architectures that match the physical and biological requirements of the bladder.",

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author = "Baker, {S. C.} and J. Southgate",

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year = "2011",

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AU - Southgate, J.

N1 - Funding Information: The authors thank Felix Wezel for critical review of the manuscript. Jennifer Southgate is supported by York Against Cancer.

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AB - organ donor shortages have driven the search for tissue engineering and regenerative solutions in many tissue pathologies, but disorders of the urinary bladder have no allograft solution. Currently, end-stage bladder disease is addressed by reconstructing the bladder with vascularised segments of bowel, but serious long-term side-effects correspond to a clinical need to develop new approaches. the application of electrospun biomaterials, in combination with in vitro tissue engineering or in vivo regenerative engineering strategies, holds elusive promise for routine bladder augmentation or substitution. The major challenges include identification of suitable elastic/biodegradable polymers and scaffold architectures that match the physical and biological requirements of the bladder.

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KW - Bladder regeneration

KW - Electrospun polystyrene

KW - Urinary tract tissue engineering

KW - Urothelium

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M3 - Chapter

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SN - 9781845697419

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EP - 241

BT - Electrospinning for Tissue Regeneration

PB - Elsevier

ER -

Bladder tissue regeneration

Abstract

Bibliographical note

Keywords

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