Abstract
This chapter reviews the use of engineering and biomaterials approaches aimed at improving the capacity and compliance of the diseased urinary bladder. The chapter introduces the normal bladder and describes the clinical background that drives the need for bladder tissue replacement and/or reconstruction. It examines a variety of synthetic and natural matrices developed for different strategies in bladder reconstruction from both historic and contemporary perspectives, and provides a critical review of the results to date, including a discussion of the steps needed to realize bladder tissue engineering in patients. Although progress has been made, the need for materials that offer the unique requirements for use in the bladder remains unmet and offers an open opportunity for future research champions in the fields of biomaterials, tissue engineering, and regenerative medicine.
| Original language | English |
|---|---|
| Title of host publication | Tissue Engineering Using Ceramics and Polymers |
| Publisher | Elsevier |
| Chapter | 12 |
| Pages | 459-480 |
| Number of pages | 22 |
| Edition | Third |
| ISBN (Electronic) | 9780128205082 |
| ISBN (Print) | 9780128205792 |
| DOIs | |
| Publication status | Published - 19 Nov 2021 |
Bibliographical note
Publisher Copyright:© 2022 Elsevier Ltd. All rights reserved.
Keywords
- Acellular matrix
- Bladder augmentation
- Bladder reconstruction
- Enterocystoplasty
- Natural biomaterials
- Synthetic polymers
- Tissue engineering
- Urinary bladder