Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development

B J Casey; C E Glatt; N Tottenham; F Soliman; K Bath; D Amso; M Altemus; S Pattwell; R Jones; L Levita; B McEwen; A M Magariños; M Gunnar; K M Thomas; J Mezey; A G Clark; B L Hempstead; F S Lee

doi:10.1016/j.neuroscience.2009.03.081

Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development

B J Casey, C E Glatt, N Tottenham, F Soliman, K Bath, D Amso, M Altemus, S Pattwell, R Jones, L Levita, B McEwen, A M Magariños, M Gunnar, K M Thomas, J Mezey, A G Clark, B L Hempstead, F S Lee

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans.

Original language	English
Pages (from-to)	108-20
Number of pages	13
Journal	Neuroscience
Volume	164
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroscience.2009.03.081
Publication status	Published - 24 Nov 2009

Keywords

Aging
Animals
Brain
Brain-Derived Neurotrophic Factor
Environment
Human Development
Humans
Mice
Models, Genetic
Phenotype
Polymorphism, Genetic

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10.1016/j.neuroscience.2009.03.081

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Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magariños, A. M., Gunnar, M., Thomas, K. M., Mezey, J., Clark, A. G., Hempstead, B. L., & Lee, F. S. (2009). Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience, 164(1), 108-20. https://doi.org/10.1016/j.neuroscience.2009.03.081

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abstract = "There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans.",

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Casey, BJ, Glatt, CE, Tottenham, N, Soliman, F, Bath, K, Amso, D, Altemus, M, Pattwell, S, Jones, R, Levita, L, McEwen, B, Magariños, AM, Gunnar, M, Thomas, KM, Mezey, J, Clark, AG, Hempstead, BL & Lee, FS 2009, 'Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development', Neuroscience, vol. 164, no. 1, pp. 108-20. https://doi.org/10.1016/j.neuroscience.2009.03.081

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AU - Altemus, M

AU - Pattwell, S

AU - Jones, R

AU - Levita, L

AU - McEwen, B

AU - Magariños, A M

AU - Gunnar, M

AU - Thomas, K M

AU - Mezey, J

AU - Clark, A G

AU - Hempstead, B L

AU - Lee, F S

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Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development

Abstract

Keywords

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