Abstract
Disruption of host membranes by nonenveloped viruses, which allows the nucleocapsid or genome to enter the cytosol, is a mechanistically diverse process. Although the membrane-penetrating agents are usually small, hydrophobic or amphipathic peptides deployed from the capsid interior during entry, their manner of membrane interaction varies substantially. In this review, we discuss recent data about the molecular pathways for externalization of viral peptides amidst conformational alterations in the capsid, as well as mechanisms of membrane penetration, which is influenced by structural features of the peptides themselves as well as physicochemical properties of membranes, and other host factors. The membrane-penetrating components of nonenveloped viruses constitute an interesting class of cell-penetrating peptides, and may have potential therapeutic value for gene transfer.
| Original language | English |
|---|---|
| Pages (from-to) | 525-537 |
| Number of pages | 13 |
| Journal | Trends in microbiology |
| Volume | 26 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2018 |
Bibliographical note
Copyright © 2017 Elsevier Ltd. All rights reserved.Keywords
- Capsid/physiology
- Capsid Proteins/physiology
- Cell Membrane/virology
- Cell-Penetrating Peptides/physiology
- Cytosol/virology
- Host Microbial Interactions
- Humans
- Polyomavirus/physiology
- Simian virus 40/physiology
- Virion/physiology
- Virus Internalization