BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa

Fredrick Katongole; Tiyara Arumugam; Angus Jennings; Constantine Mutata; Patrick Ssebunya; Charity Wamboi; Alexandra Green; Mutsa Bwakura Dangarembizi; Cissy Kityo; Abraham M. Siika; Moherndran Archary; Lungile Jafta; Stella Namukwaya; Janet Seeley; Henry Mugerwa; Simon Walker; Naomi Apoto; Margaret J. Thomason; Deborah Ford; Sarah Pett; Adeodata R. Kekitiinwa

doi:10.2139/ssrn.5152849

BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa

Fredrick Katongole, Tiyara Arumugam, Angus Jennings, Constantine Mutata, Patrick Ssebunya, Charity Wamboi, Alexandra Green, Mutsa Bwakura Dangarembizi, Cissy Kityo, Abraham M. Siika, Moherndran Archary, Lungile Jafta, Stella Namukwaya, Janet Seeley, Henry Mugerwa, Simon Walker, Naomi Apoto, Margaret J. Thomason, Deborah Ford, Sarah PettAdeodata R. Kekitiinwa

Centre for Health Economics

Research output: Working paper

Original language	English
Publisher	SSRN
DOIs	https://doi.org/10.2139/ssrn.5152849
Publication status	Published - 4 Mar 2025

Access to Document

10.2139/ssrn.5152849

https://ssrn.com/abstract=5152849

Cite this

Katongole, F., Arumugam, T., Jennings, A., Mutata, C., Ssebunya, P., Wamboi, C., Green, A., Dangarembizi, M. B., Kityo, C., Siika, A. M., Archary, M., Jafta, L., Namukwaya, S., Seeley, J., Mugerwa, H., Walker, S., Apoto, N., Thomason, M. J., Ford, D., ... Kekitiinwa, A. R. (2025). BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa. SSRN. https://doi.org/10.2139/ssrn.5152849

Katongole, Fredrick ; Arumugam, Tiyara ; Jennings, Angus et al. / BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa. SSRN, 2025.

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title = "BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa",

author = "Fredrick Katongole and Tiyara Arumugam and Angus Jennings and Constantine Mutata and Patrick Ssebunya and Charity Wamboi and Alexandra Green and Dangarembizi, {Mutsa Bwakura} and Cissy Kityo and Siika, {Abraham M.} and Moherndran Archary and Lungile Jafta and Stella Namukwaya and Janet Seeley and Henry Mugerwa and Simon Walker and Naomi Apoto and Thomason, {Margaret J.} and Deborah Ford and Sarah Pett and Kekitiinwa, {Adeodata R.}",

year = "2025",

month = mar,

day = "4",

doi = "10.2139/ssrn.5152849",

language = "English",

publisher = "SSRN",

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Katongole, F, Arumugam, T, Jennings, A, Mutata, C, Ssebunya, P, Wamboi, C, Green, A, Dangarembizi, MB, Kityo, C, Siika, AM, Archary, M, Jafta, L, Namukwaya, S, Seeley, J, Mugerwa, H, Walker, S, Apoto, N, Thomason, MJ, Ford, D, Pett, S & Kekitiinwa, AR 2025 'BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa' SSRN. https://doi.org/10.2139/ssrn.5152849

BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa. / Katongole, Fredrick; Arumugam, Tiyara; Jennings, Angus et al.
SSRN, 2025.

Research output: Working paper

TY - UNPB

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AU - Katongole, Fredrick

AU - Arumugam, Tiyara

AU - Jennings, Angus

AU - Mutata, Constantine

AU - Ssebunya, Patrick

AU - Wamboi, Charity

AU - Green, Alexandra

AU - Dangarembizi, Mutsa Bwakura

AU - Kityo, Cissy

AU - Siika, Abraham M.

AU - Archary, Moherndran

AU - Jafta, Lungile

AU - Namukwaya, Stella

AU - Seeley, Janet

AU - Mugerwa, Henry

AU - Walker, Simon

AU - Apoto, Naomi

AU - Thomason, Margaret J.

AU - Ford, Deborah

AU - Pett, Sarah

AU - Kekitiinwa, Adeodata R.

PY - 2025/3/4

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DO - 10.2139/ssrn.5152849

M3 - Working paper

BT - BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa

PB - SSRN

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Katongole F, Arumugam T, Jennings A, Mutata C, Ssebunya P, Wamboi C et al. BREATHER Plus Clinical Trial Design: A Randomised Non-Inferiority Trial Evaluating the Efficacy, Safety and Acceptability of Short Cycle (Five Days on, Two Days Off) Dolutegravir/Tenofovir-Based Triple Antiretroviral Therapy (Art) Compared to Daily Art in Virologically Suppressed Adolescents Living with HIV Aged 12 to <20 Years in Sub-Saharan Africa. SSRN. 2025 Mar 4. doi: 10.2139/ssrn.5152849