Bridging the Gap between Glycosylation and Vesicle Traffic

TY - JOUR

T1 - Bridging the Gap between Glycosylation and Vesicle Traffic

AU - Fisher, Peter

AU - Ungar, Daniel

N1 - ©2016 Fisher and Ungar.

PY - 2016/3/8

Y1 - 2016/3/8

N2 - Glycosylation is recognized as a vitally important posttranslational modification. The structure of glycans that decorate proteins and lipids is largely dictated by biosynthetic reactions occurring in the Golgi apparatus. This biosynthesis relies on the relative distribution of glycosyltransferases and glycosidases, which is maintained by retrograde vesicle traffic between Golgi cisternae. Tethering of vesicles at the Golgi apparatus prior to fusion is regulated by Rab GTPases, coiled-coil tethers termed golgins and the multisubunit tethering complex known as the conserved oligomeric Golgi (COG) complex. In this review we discuss the mechanisms involved in vesicle tethering at the Golgi apparatus and highlight the importance of tethering in the context of glycan biosynthesis and a set of diseases known as congenital disorders of glycosylation.

AB - Glycosylation is recognized as a vitally important posttranslational modification. The structure of glycans that decorate proteins and lipids is largely dictated by biosynthetic reactions occurring in the Golgi apparatus. This biosynthesis relies on the relative distribution of glycosyltransferases and glycosidases, which is maintained by retrograde vesicle traffic between Golgi cisternae. Tethering of vesicles at the Golgi apparatus prior to fusion is regulated by Rab GTPases, coiled-coil tethers termed golgins and the multisubunit tethering complex known as the conserved oligomeric Golgi (COG) complex. In this review we discuss the mechanisms involved in vesicle tethering at the Golgi apparatus and highlight the importance of tethering in the context of glycan biosynthesis and a set of diseases known as congenital disorders of glycosylation.

KW - Golgi apparatus, glycan processing, COG complex, Congenital disorders of glycosylation, vesicle tethering

U2 - 10.3389/fcell.2016.00015

DO - 10.3389/fcell.2016.00015

M3 - Article

C2 - 27014691

SN - 2296-634X

VL - 4

JO - Frontiers in cell and developmental biology

JF - Frontiers in cell and developmental biology

M1 - 15

ER -