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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. / Oxford Immunology Network Covid-19 Response T cell Consortium.

In: Nature immunology, Vol. 21, No. 11, 11.2020, p. 1336–1345.

Research output: Contribution to journalArticlepeer-review

Harvard

Oxford Immunology Network Covid-19 Response T cell Consortium 2020, 'Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19', Nature immunology, vol. 21, no. 11, pp. 1336–1345. https://doi.org/10.1038/s41590-020-0782-6

APA

Oxford Immunology Network Covid-19 Response T cell Consortium (2020). Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. Nature immunology, 21(11), 1336–1345. https://doi.org/10.1038/s41590-020-0782-6

Vancouver

Oxford Immunology Network Covid-19 Response T cell Consortium. Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. Nature immunology. 2020 Nov;21(11):1336–1345. https://doi.org/10.1038/s41590-020-0782-6

Author

Oxford Immunology Network Covid-19 Response T cell Consortium. / Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. In: Nature immunology. 2020 ; Vol. 21, No. 11. pp. 1336–1345.

Bibtex - Download

@article{e6da6253f2904b47b2a958cee09ef772,
title = "Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19",
abstract = "The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide-MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.",
author = "{Oxford Immunology Network Covid-19 Response T cell Consortium} and Yanchun Peng and Mentzer, {Alexander J} and Guihai Liu and Xuan Yao and Zixi Yin and Danning Dong and Wanwisa Dejnirattisai and Timothy Rostron and Piyada Supasa and Chang Liu and C{\'e}sar L{\'o}pez-Camacho and Jose Slon-Campos and Yuguang Zhao and Stuart, {David I} and Paesen, {Guido C} and Grimes, {Jonathan M} and Antson, {Alfred A} and Bayfield, {Oliver W} and Hawkins, {Dorothy E D P} and De-Sheng Ker and Beibei Wang and Lance Turtle and Krishanthi Subramaniam and Paul Thomson and Ping Zhang and Christina Dold and Jeremy Ratcliff and Peter Simmonds and {de Silva}, Thushan and Paul Sopp and Dannielle Wellington and Ushani Rajapaksa and Yi-Ling Chen and Mariolina Salio and Giorgio Napolitani and Wayne Paes and Persephone Borrow and Kessler, {Benedikt M} and Fry, {Jeremy W} and Schwabe, {Nikolai F} and Semple, {Malcolm G} and Baillie, {J Kenneth} and Moore, {Shona C} and Openshaw, {Peter J M} and Ansari, {M Azim} and Susanna Dunachie and Eleanor Barnes and John Frater and Georgina Kerr and Philip Goulder",
note = "{\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details.",
year = "2020",
month = nov,
doi = "10.1038/s41590-020-0782-6",
language = "English",
volume = "21",
pages = "1336–1345",
journal = "Nature immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "11",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

AU - Oxford Immunology Network Covid-19 Response T cell Consortium

AU - Peng, Yanchun

AU - Mentzer, Alexander J

AU - Liu, Guihai

AU - Yao, Xuan

AU - Yin, Zixi

AU - Dong, Danning

AU - Dejnirattisai, Wanwisa

AU - Rostron, Timothy

AU - Supasa, Piyada

AU - Liu, Chang

AU - López-Camacho, César

AU - Slon-Campos, Jose

AU - Zhao, Yuguang

AU - Stuart, David I

AU - Paesen, Guido C

AU - Grimes, Jonathan M

AU - Antson, Alfred A

AU - Bayfield, Oliver W

AU - Hawkins, Dorothy E D P

AU - Ker, De-Sheng

AU - Wang, Beibei

AU - Turtle, Lance

AU - Subramaniam, Krishanthi

AU - Thomson, Paul

AU - Zhang, Ping

AU - Dold, Christina

AU - Ratcliff, Jeremy

AU - Simmonds, Peter

AU - de Silva, Thushan

AU - Sopp, Paul

AU - Wellington, Dannielle

AU - Rajapaksa, Ushani

AU - Chen, Yi-Ling

AU - Salio, Mariolina

AU - Napolitani, Giorgio

AU - Paes, Wayne

AU - Borrow, Persephone

AU - Kessler, Benedikt M

AU - Fry, Jeremy W

AU - Schwabe, Nikolai F

AU - Semple, Malcolm G

AU - Baillie, J Kenneth

AU - Moore, Shona C

AU - Openshaw, Peter J M

AU - Ansari, M Azim

AU - Dunachie, Susanna

AU - Barnes, Eleanor

AU - Frater, John

AU - Kerr, Georgina

AU - Goulder, Philip

N1 - © The Author(s), under exclusive licence to Springer Nature America, Inc. 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2020/11

Y1 - 2020/11

N2 - The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide-MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.

AB - The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4+ and/or CD8+ epitopes, including six immunodominant regions. Six optimized CD8+ epitopes were defined, with peptide-MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.

U2 - 10.1038/s41590-020-0782-6

DO - 10.1038/s41590-020-0782-6

M3 - Article

C2 - 32887977

VL - 21

SP - 1336

EP - 1345

JO - Nature immunology

JF - Nature immunology

SN - 1529-2908

IS - 11

ER -