Carbon Monoxide-Releasing Molecules: Design Principles Inspired by Mechanism, Enabling Activity to be Controlled and Tuned

TY - CHAP

T1 - Carbon Monoxide-Releasing Molecules

T2 - Design Principles Inspired by Mechanism, Enabling Activity to be Controlled and Tuned

AU - Fairlamb, Ian J.S.

AU - Lynam, Jason M.

PY - 2018/12/6

Y1 - 2018/12/6

N2 - Advances in the design, synthesis, mechanism of action and activity of transition metal-based carbon monoxide-releasing molecules (CO-RMs) as potential therapeutic agents are described in ths chapter. The synthesis of complexes which contain organic ligands coordinated to metal complexes in a variety of different binding modes are described. An evaluation of how the structure of the metal complex, the nature of the ligand, and the manner in which it is coordinated affect the CO-releasing properties gives vital insight into how CO is liberated from the metal. Studies of reaction mechanisms demonstrate that the factors controlling the CO-release process are complex and frequently involve initial interaction with the medium, rather than a simple metal-carbon bond cleavage. The implementation of manganese-based CO-RMs in which CO-dissociation is induced by light (PhotoCORMs) are described as the subsequent antibiotic activity of the lead complex, TryptoCORM, which shows activity against E. Coli, N. gonorroheae, and S. aureus bacteria.

AB - Advances in the design, synthesis, mechanism of action and activity of transition metal-based carbon monoxide-releasing molecules (CO-RMs) as potential therapeutic agents are described in ths chapter. The synthesis of complexes which contain organic ligands coordinated to metal complexes in a variety of different binding modes are described. An evaluation of how the structure of the metal complex, the nature of the ligand, and the manner in which it is coordinated affect the CO-releasing properties gives vital insight into how CO is liberated from the metal. Studies of reaction mechanisms demonstrate that the factors controlling the CO-release process are complex and frequently involve initial interaction with the medium, rather than a simple metal-carbon bond cleavage. The implementation of manganese-based CO-RMs in which CO-dissociation is induced by light (PhotoCORMs) are described as the subsequent antibiotic activity of the lead complex, TryptoCORM, which shows activity against E. Coli, N. gonorroheae, and S. aureus bacteria.

KW - 2-pyrones

KW - Carbon monoxide

KW - CO-RMs

KW - Metal carbene complexes

KW - Metal carbonyls

KW - Metallodrugs

KW - Novel antibiotics

KW - Photochemical activation

KW - Reaction mechanism

UR - http://www.scopus.com/inward/record.url?scp=85074658110&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-814197-7.00007-8

DO - 10.1016/B978-0-12-814197-7.00007-8

M3 - Chapter

SN - 9780128141977

SP - 137

EP - 154

BT - Advances in Bioorganometallic Chemistry

PB - Elsevier

ER -