Carbon Monoxide-Releasing Molecules: Design Principles Inspired by Mechanism, Enabling Activity to be Controlled and Tuned

Research output: Chapter in Book/Report/Conference proceedingChapter

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Publication details

Title of host publicationAdvances in Bioorganometallic Chemistry
DatePublished - 6 Dec 2018
Pages137-154
Number of pages18
PublisherElsevier
Original languageEnglish
ISBN (Electronic)9780128141984
ISBN (Print)9780128141977

Abstract

Advances in the design, synthesis, mechanism of action and activity of transition metal-based carbon monoxide-releasing molecules (CO-RMs) as potential therapeutic agents are described in ths chapter. The synthesis of complexes which contain organic ligands coordinated to metal complexes in a variety of different binding modes are described. An evaluation of how the structure of the metal complex, the nature of the ligand, and the manner in which it is coordinated affect the CO-releasing properties gives vital insight into how CO is liberated from the metal. Studies of reaction mechanisms demonstrate that the factors controlling the CO-release process are complex and frequently involve initial interaction with the medium, rather than a simple metal-carbon bond cleavage. The implementation of manganese-based CO-RMs in which CO-dissociation is induced by light (PhotoCORMs) are described as the subsequent antibiotic activity of the lead complex, TryptoCORM, which shows activity against E. Coli, N. gonorroheae, and S. aureus bacteria.

    Research areas

  • 2-pyrones, Carbon monoxide, CO-RMs, Metal carbene complexes, Metal carbonyls, Metallodrugs, Novel antibiotics, Photochemical activation, Reaction mechanism

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