The York Research Database

Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments

Packer, J. R., Hirst, A. M., Droop, A. P., Adamson, R., Simms, M. S., Mann, V. M., Frame, F. M., O'Connell, D. & Maitland, N. J., 17 Sep 2019

Article in FEBS Letters

Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance

Frame, F. M. & Maitland, N. J., 17 May 2019

Review article in International Journal of Molecular Sciences

The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy

Seed, R. I., Taurozzi, A. J., Wilcock, D. J., Nappo, G., Erb, H. H. H., Read, M. L., Gurney, M., Archer, L. K., Ito, S., Rumsby, M. G., Petrie, J. L., Clayton, A., Maitland, N. J. & Collins, A. T., 26 Mar 2019

Article in Scientific Reports

Effects on prostate cancer cells of targeting RNA polymerase III

Petrie, J. L., Swan, C., Ingram, R. M., Frame, F. M., Collins, A. T., Dumay-Odelot, H., Teichmann, M., Maitland, N. J. & White, R. J., 1 Mar 2019

Article in Nucleic Acids Research

Phenotype-independent DNA methylation changes in prostate cancer

Pellacani, D., Droop, A. P., Frame, F. M., Simms, M. S., Mann, V. M., Collins, A. T., Eaves, C. J. & Maitland, N. J., 15 Oct 2018

Article in British journal of cancer

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth

Casara, P., Davidson, J., Claperon, A., Toumelin-Braizat, G. L., Vogler, M., Bruno, A., Chanrion, M., Lysiak-Auvity, G., Diguarher, T. L., Starck, J-B., Chen, I., Whitehead, N., Graham, C., Matassova, N., Dokurno, P., Pedder, C., Wang, Y., Qiu, S., Girard, A-M., Schneider, E. & 18 othersGravé, F., Studeny, A., Guasconi, G., Rocchetti, F., Maïga, S., Henlin, J-M., Colland, F., Kraus-Berthier, L., Gouill, S. L., Dyer, M. JS., Hubbard, R., Wood, M., Amiot, M., Cohen, G. M., Hickman, J. A., Morris, E., Murray, J. & Geneste, O., 13 Apr 2018

Article in Oncotarget

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

Butler, D. E., Marlein, C., Walker, H. F., Frame, F. M., Mann, V. M., Simms, M. S., Davies, B. R., Collins, A. T. & Maitland, N. J., 23 May 2017

Article in Oncotarget

IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines

Thurber, A., Nelson, M., Frost, C., Levin, M., Brackenbury, W. J. & Kaplan, D. L., 21 Mar 2017

Article in Oncotarget

Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia

Laidlaw, K. M. E., Berhan, S., Liu, S., Silvestri, G., Holyoake, T. L., Frank, D. A., Aggarwal, B., Bonner, M. Y., Perrotti, D., Jørgensen, H. G. & Arbiser, J. L., 9 Aug 2016

Article in Oncotarget

Inhibition of the glucocorticoid receptor results in an enhanced miR-99a/100-mediated radiation response in stem-like cells from human prostate cancers

Rane, J. K., Erb, H. H., Nappo, G., Mann, V. M., Simms, M. S., Collins, A. T., Visakorpi, T. & Maitland, N. J., 21 Jun 2016

Article in Oncotarget