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CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial

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CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder) : study protocol for a randomised controlled trial. / Overend, Karen Jane; Lewis, Helen; Bailey, Della; Bosanquet, Kate; Chew-Graham, Carolyn; Ekers, David; Gascoyne, Samantha; Hems, Deborah; Holmes, John; Keding, Ada; McMillan, Dean; Meer, Shaista; Mitchell, Natasha; Nutbrown, Sarah; Parrott, Steve; Richards, David; Traviss, Gemma; Trépel, Dominic; Woodhouse, Rebecca; Gilbody, Simon.

In: Trials, Vol. 15, 451, 19.11.2014.

Research output: Contribution to journalArticle

Harvard

Overend, KJ, Lewis, H, Bailey, D, Bosanquet, K, Chew-Graham, C, Ekers, D, Gascoyne, S, Hems, D, Holmes, J, Keding, A, McMillan, D, Meer, S, Mitchell, N, Nutbrown, S, Parrott, S, Richards, D, Traviss, G, Trépel, D, Woodhouse, R & Gilbody, S 2014, 'CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial', Trials, vol. 15, 451. https://doi.org/10.1186/1745-6215-15-451

APA

Overend, K. J., Lewis, H., Bailey, D., Bosanquet, K., Chew-Graham, C., Ekers, D., ... Gilbody, S. (2014). CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial. Trials, 15, [451]. https://doi.org/10.1186/1745-6215-15-451

Vancouver

Overend KJ, Lewis H, Bailey D, Bosanquet K, Chew-Graham C, Ekers D et al. CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial. Trials. 2014 Nov 19;15. 451. https://doi.org/10.1186/1745-6215-15-451

Author

Overend, Karen Jane ; Lewis, Helen ; Bailey, Della ; Bosanquet, Kate ; Chew-Graham, Carolyn ; Ekers, David ; Gascoyne, Samantha ; Hems, Deborah ; Holmes, John ; Keding, Ada ; McMillan, Dean ; Meer, Shaista ; Mitchell, Natasha ; Nutbrown, Sarah ; Parrott, Steve ; Richards, David ; Traviss, Gemma ; Trépel, Dominic ; Woodhouse, Rebecca ; Gilbody, Simon. / CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder) : study protocol for a randomised controlled trial. In: Trials. 2014 ; Vol. 15.

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@article{0aba6a8dc77d427d92bd654666a5e896,
title = "CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial",
abstract = "BACKGROUND: Depression accounts for the greatest disease burden of all mental health disorders, contributes heavily to healthcare costs, and by 2020 is set to become the second largest cause of global disability. Although 10{\%} to 16{\%} of people aged 65 years and over are likely to experience depressive symptoms, the condition is under-diagnosed and often inadequately treated in primary care. Later-life depression is associated with chronic illness and disability, cognitive impairment and social isolation. With a progressively ageing population it becomes increasingly important to refine strategies to identity and manage depression in older people. Currently, management may be limited to the prescription of antidepressants where there may be poor concordance; older people may lack awareness of psychosocial interventions and general practitioners may neglect to offer this treatment option.Methods/design: CASPER Plus is a multi-centre, randomised controlled trial of a collaborative care intervention for individuals aged 65 years and over experiencing moderate to severe depression. Selected practices in the North of England identify potentially eligible patients and invite them to participate in the study. A diagnostic interview is carried out and participants with major depressive disorder are randomised to either collaborative care or usual care. The recruitment target is 450 participants.The intervention, behavioural activation and medication management in a collaborative care framework, has been adapted to meet the complex needs of older people. It is delivered over eight to 10 weekly sessions by a case manager liaising with general practitioners.The trial aims to evaluate the clinical and cost effectiveness of collaborative care in addition to usual GP care versus usual GP care alone. The primary clinical outcome, depression severity, will be measured with the Patient Health Questionnaire-9 (PHQ-9) at baseline, 4, 12 and 18 months. Cost effectiveness analysis will assess health-related quality of life using the SF-12 and EQ-5D and will examine cost-consequences of collaborative care.A qualitative process evaluation will be undertaken to explore acceptability, gauge the extent to which the intervention is implemented and to explore sustainability beyond the clinical trial. DISCUSSION: Results will add to existing evidence and a positive outcome may lead to the commissioning of this model of service in primary care.Trial registration: ISRCTN45842879 (24 July 2012).",
author = "Overend, {Karen Jane} and Helen Lewis and Della Bailey and Kate Bosanquet and Carolyn Chew-Graham and David Ekers and Samantha Gascoyne and Deborah Hems and John Holmes and Ada Keding and Dean McMillan and Shaista Meer and Natasha Mitchell and Sarah Nutbrown and Steve Parrott and David Richards and Gemma Traviss and Dominic Tr{\'e}pel and Rebecca Woodhouse and Simon Gilbody",
year = "2014",
month = "11",
day = "19",
doi = "10.1186/1745-6215-15-451",
language = "English",
volume = "15",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder)

T2 - Trials

AU - Overend, Karen Jane

AU - Lewis, Helen

AU - Bailey, Della

AU - Bosanquet, Kate

AU - Chew-Graham, Carolyn

AU - Ekers, David

AU - Gascoyne, Samantha

AU - Hems, Deborah

AU - Holmes, John

AU - Keding, Ada

AU - McMillan, Dean

AU - Meer, Shaista

AU - Mitchell, Natasha

AU - Nutbrown, Sarah

AU - Parrott, Steve

AU - Richards, David

AU - Traviss, Gemma

AU - Trépel, Dominic

AU - Woodhouse, Rebecca

AU - Gilbody, Simon

PY - 2014/11/19

Y1 - 2014/11/19

N2 - BACKGROUND: Depression accounts for the greatest disease burden of all mental health disorders, contributes heavily to healthcare costs, and by 2020 is set to become the second largest cause of global disability. Although 10% to 16% of people aged 65 years and over are likely to experience depressive symptoms, the condition is under-diagnosed and often inadequately treated in primary care. Later-life depression is associated with chronic illness and disability, cognitive impairment and social isolation. With a progressively ageing population it becomes increasingly important to refine strategies to identity and manage depression in older people. Currently, management may be limited to the prescription of antidepressants where there may be poor concordance; older people may lack awareness of psychosocial interventions and general practitioners may neglect to offer this treatment option.Methods/design: CASPER Plus is a multi-centre, randomised controlled trial of a collaborative care intervention for individuals aged 65 years and over experiencing moderate to severe depression. Selected practices in the North of England identify potentially eligible patients and invite them to participate in the study. A diagnostic interview is carried out and participants with major depressive disorder are randomised to either collaborative care or usual care. The recruitment target is 450 participants.The intervention, behavioural activation and medication management in a collaborative care framework, has been adapted to meet the complex needs of older people. It is delivered over eight to 10 weekly sessions by a case manager liaising with general practitioners.The trial aims to evaluate the clinical and cost effectiveness of collaborative care in addition to usual GP care versus usual GP care alone. The primary clinical outcome, depression severity, will be measured with the Patient Health Questionnaire-9 (PHQ-9) at baseline, 4, 12 and 18 months. Cost effectiveness analysis will assess health-related quality of life using the SF-12 and EQ-5D and will examine cost-consequences of collaborative care.A qualitative process evaluation will be undertaken to explore acceptability, gauge the extent to which the intervention is implemented and to explore sustainability beyond the clinical trial. DISCUSSION: Results will add to existing evidence and a positive outcome may lead to the commissioning of this model of service in primary care.Trial registration: ISRCTN45842879 (24 July 2012).

AB - BACKGROUND: Depression accounts for the greatest disease burden of all mental health disorders, contributes heavily to healthcare costs, and by 2020 is set to become the second largest cause of global disability. Although 10% to 16% of people aged 65 years and over are likely to experience depressive symptoms, the condition is under-diagnosed and often inadequately treated in primary care. Later-life depression is associated with chronic illness and disability, cognitive impairment and social isolation. With a progressively ageing population it becomes increasingly important to refine strategies to identity and manage depression in older people. Currently, management may be limited to the prescription of antidepressants where there may be poor concordance; older people may lack awareness of psychosocial interventions and general practitioners may neglect to offer this treatment option.Methods/design: CASPER Plus is a multi-centre, randomised controlled trial of a collaborative care intervention for individuals aged 65 years and over experiencing moderate to severe depression. Selected practices in the North of England identify potentially eligible patients and invite them to participate in the study. A diagnostic interview is carried out and participants with major depressive disorder are randomised to either collaborative care or usual care. The recruitment target is 450 participants.The intervention, behavioural activation and medication management in a collaborative care framework, has been adapted to meet the complex needs of older people. It is delivered over eight to 10 weekly sessions by a case manager liaising with general practitioners.The trial aims to evaluate the clinical and cost effectiveness of collaborative care in addition to usual GP care versus usual GP care alone. The primary clinical outcome, depression severity, will be measured with the Patient Health Questionnaire-9 (PHQ-9) at baseline, 4, 12 and 18 months. Cost effectiveness analysis will assess health-related quality of life using the SF-12 and EQ-5D and will examine cost-consequences of collaborative care.A qualitative process evaluation will be undertaken to explore acceptability, gauge the extent to which the intervention is implemented and to explore sustainability beyond the clinical trial. DISCUSSION: Results will add to existing evidence and a positive outcome may lead to the commissioning of this model of service in primary care.Trial registration: ISRCTN45842879 (24 July 2012).

U2 - 10.1186/1745-6215-15-451

DO - 10.1186/1745-6215-15-451

M3 - Article

VL - 15

JO - Trials

JF - Trials

SN - 1745-6215

M1 - 451

ER -