Catalyst-driven scaffold diversity: selective synthesis of spirocycles, carbazoles and quinolines from indolyl ynones

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Medicinally relevant spirocyclic indolenines, carbazoles and quinolines can each be directly synthesised selectively from common indolyl ynone starting materials by catalyst variation. The high yielding, divergent reactions all proceed via an initial dearomatising spirocyclisation reaction to generate an intermediate vinyl metal species which then rearranges selectively by careful choice of catalyst and reaction conditions.

Original languageEnglish
Pages (from-to)8777–8780
Number of pages4
JournalChemistry : A European Journal
Issue number26
Early online date19 May 2016
Publication statusPublished - 20 Jun 2016

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  • carbazoles
  • catalysis
  • diversity
  • quinolines
  • spirocycles
  • Stereoisomerism
  • Spiro Compounds/chemical synthesis
  • Indoles/chemistry
  • Carbazoles/chemical synthesis
  • Catalysis
  • Mesylates/chemistry
  • Quinolines/chemical synthesis

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