Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Anand Manoharan; Peter J Rayner; Marianna Fekete; Wissam Iali; Philip Norcott; V Hugh Perry; Simon B Duckett

doi:10.1002/cphc.201800915

Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Anand Manoharan, Peter J Rayner, Marianna Fekete, Wissam Iali, Philip Norcott, V Hugh Perry, Simon B Duckett

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	ChemPhysChem
Volume	20
Issue number	2
Early online date	27 Nov 2018
DOIs	https://doi.org/10.1002/cphc.201800915
Publication status	Published - 21 Jan 2019

Bibliographical note

Keywords

Antitubercular Agents/chemistry
Biocompatible Materials/chemistry
Catalysis
Cell Line, Tumor
Cell Survival/drug effects
Coordination Complexes/chemistry
Deuterium/chemistry
Humans
Iridium/chemistry
Isoniazid/chemistry
Methane/analogs & derivatives
Pyrazinamide/chemistry
Substrate Specificity

Access to Document

10.1002/cphc.201800915

Hyperpolarisation using SABRE as a new tool for imaging
Duckett, S. B. (Principal investigator) & Green, G. G. R. (Co-investigator)
1/10/12 → 31/03/19
Project: Research project (funded) › Research

Cite this

@article{6d1216d3092f4fcc9e71c13f2c1a950e,

title = "Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization",

abstract = "The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.",

keywords = "Antitubercular Agents/chemistry, Biocompatible Materials/chemistry, Catalysis, Cell Line, Tumor, Cell Survival/drug effects, Coordination Complexes/chemistry, Deuterium/chemistry, Humans, Iridium/chemistry, Isoniazid/chemistry, Methane/analogs & derivatives, Pyrazinamide/chemistry, Substrate Specificity",

author = "Anand Manoharan and Rayner, {Peter J} and Marianna Fekete and Wissam Iali and Philip Norcott and {Hugh Perry}, V and Duckett, {Simon B}",

note = "{\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2019",

month = jan,

day = "21",

doi = "10.1002/cphc.201800915",

language = "English",

volume = "20",

pages = "285--294",

journal = "ChemPhysChem",

issn = "1439-4235",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

AU - Manoharan, Anand

AU - Rayner, Peter J

AU - Fekete, Marianna

AU - Iali, Wissam

AU - Norcott, Philip

AU - Hugh Perry, V

AU - Duckett, Simon B

PY - 2019/1/21

Y1 - 2019/1/21

N2 - The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

AB - The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

KW - Antitubercular Agents/chemistry

KW - Biocompatible Materials/chemistry

KW - Catalysis

KW - Cell Line, Tumor

KW - Cell Survival/drug effects

KW - Coordination Complexes/chemistry

KW - Deuterium/chemistry

KW - Humans

KW - Iridium/chemistry

KW - Isoniazid/chemistry

KW - Methane/analogs & derivatives

KW - Pyrazinamide/chemistry

KW - Substrate Specificity

U2 - 10.1002/cphc.201800915

DO - 10.1002/cphc.201800915

M3 - Article

C2 - 30395699

SN - 1439-4235

VL - 20

SP - 285

EP - 294

JO - ChemPhysChem

JF - ChemPhysChem

IS - 2

ER -

Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Abstract

Bibliographical note

Keywords

Access to Document

Projects

Hyperpolarisation using SABRE as a new tool for imaging

Cite this