Projects per year
Abstract
The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.
Original language | English |
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Pages (from-to) | 285-294 |
Number of pages | 10 |
Journal | ChemPhysChem |
Volume | 20 |
Issue number | 2 |
Early online date | 27 Nov 2018 |
DOIs | |
Publication status | Published - 21 Jan 2019 |
Bibliographical note
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Keywords
- Antitubercular Agents/chemistry
- Biocompatible Materials/chemistry
- Catalysis
- Cell Line, Tumor
- Cell Survival/drug effects
- Coordination Complexes/chemistry
- Deuterium/chemistry
- Humans
- Iridium/chemistry
- Isoniazid/chemistry
- Methane/analogs & derivatives
- Pyrazinamide/chemistry
- Substrate Specificity
Projects
- 1 Finished
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Hyperpolarisation using SABRE as a new tool for imaging
Duckett, S. B. (Principal investigator) & Green, G. G. R. (Co-investigator)
1/10/12 → 31/03/19
Project: Research project (funded) › Research