CCR7 and its ligands: balancing immunity and tolerance

Reinhold Förster; Ana Clara Davalos-Misslitz; Antal Rot

doi:10.1038/nri2297

CCR7 and its ligands: balancing immunity and tolerance

Reinhold Förster, Ana Clara Davalos-Misslitz, Antal Rot

Research output: Contribution to journal › Article › peer-review

Abstract

A key feature of the immune system is its ability to induce protective immunity against pathogens while maintaining tolerance towards self and innocuous environmental antigens. Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance. This receptor is involved in organizing thymic architecture and function, lymph-node homing of naive and regulatory T cells via high endothelial venules, as well as steady state and inflammation-induced lymph-node-bound migration of dendritic cells via afferent lymphatics. Here, we focus on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.

Original language	English
Pages (from-to)	362-371
Number of pages	10
Journal	Nature reviews. Immunology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/nri2297
Publication status	Published - May 2008

Keywords

Animals
Autoimmunity
Cell Differentiation
Cell Movement
Chemokine CCL19
Chemokine CCL21
Dendritic Cells
Humans
Immune Tolerance
Immunity, Cellular
Lymph Nodes
Receptors, CCR7
T-Lymphocytes
Thymus Gland

Access to Document

10.1038/nri2297

Cite this

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title = "CCR7 and its ligands: balancing immunity and tolerance",

abstract = "A key feature of the immune system is its ability to induce protective immunity against pathogens while maintaining tolerance towards self and innocuous environmental antigens. Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance. This receptor is involved in organizing thymic architecture and function, lymph-node homing of naive and regulatory T cells via high endothelial venules, as well as steady state and inflammation-induced lymph-node-bound migration of dendritic cells via afferent lymphatics. Here, we focus on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.",

keywords = "Animals, Autoimmunity, Cell Differentiation, Cell Movement, Chemokine CCL19, Chemokine CCL21, Dendritic Cells, Humans, Immune Tolerance, Immunity, Cellular, Lymph Nodes, Receptors, CCR7, T-Lymphocytes, Thymus Gland",

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year = "2008",

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T1 - CCR7 and its ligands

T2 - balancing immunity and tolerance

AU - Förster, Reinhold

AU - Davalos-Misslitz, Ana Clara

AU - Rot, Antal

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N2 - A key feature of the immune system is its ability to induce protective immunity against pathogens while maintaining tolerance towards self and innocuous environmental antigens. Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance. This receptor is involved in organizing thymic architecture and function, lymph-node homing of naive and regulatory T cells via high endothelial venules, as well as steady state and inflammation-induced lymph-node-bound migration of dendritic cells via afferent lymphatics. Here, we focus on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.

AB - A key feature of the immune system is its ability to induce protective immunity against pathogens while maintaining tolerance towards self and innocuous environmental antigens. Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance. This receptor is involved in organizing thymic architecture and function, lymph-node homing of naive and regulatory T cells via high endothelial venules, as well as steady state and inflammation-induced lymph-node-bound migration of dendritic cells via afferent lymphatics. Here, we focus on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance.

KW - Animals

KW - Autoimmunity

KW - Cell Differentiation

KW - Cell Movement

KW - Chemokine CCL19

KW - Chemokine CCL21

KW - Dendritic Cells

KW - Humans

KW - Immune Tolerance

KW - Immunity, Cellular

KW - Lymph Nodes

KW - Receptors, CCR7

KW - T-Lymphocytes

KW - Thymus Gland

U2 - 10.1038/nri2297

DO - 10.1038/nri2297

M3 - Article

C2 - 18379575

SN - 1474-1741

VL - 8

SP - 362

EP - 371

JO - Nature reviews. Immunology

JF - Nature reviews. Immunology

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